View Full Version : 1,2 and 1,4 addition


wbloo
08-22-2008, 07:02 PM
Hey can someone please explain to me what 1,2 and 1,4 additions are in organic - for some reason I forgot how to do them. - Thanks!

pasionatdentist
08-22-2008, 08:04 PM
Lucky you that I was just reading it....

1. (1,2 addition)= happens when the temp is low (-40) and it is under kinetic control.

2. (1,4 addition) = happens in high temp and under thermodynamic control

wbloo
08-22-2008, 09:17 PM
thanks, but one more question,

with what reagents do you use for 1,2 or 1,4 additions?

tranv117
08-22-2008, 10:09 PM
theyre addition reactions so go through a carbocation. so i believe it should be polar protic solvents

GCT
08-23-2008, 01:53 PM
Hey can someone please explain to me what 1,2 and 1,4 additions are in organic - for some reason I forgot how to do them. - Thanks!

Research kinetically favored versus thermodynamically favored.