NMJ AChR upregulation causes
Nicotinic AChR upregulation:
• Spinal cord injury
• Stroke
• Burns
• Prolonged immobility
• Prolonged exposure to neuromuscular blockers
• Multiple sclerosis
• Guillain-Barre syndrome
Nicotinic AChR downregulation
• Myasthenia gravis
• Anticholinesterase poisoning
• Organophosphate poisoning
[Miller Box 29-1]