auburnO5
04-03-2012, 07:48 PM
I understand that it's made early by the embryo and then syncytiotrophoblasts to keep the corpus luteum producing progesterone.
I guess I can't figure out why it would cause an LH surge.
This is in the setting of an anovulatory/infertile female seeking fertility treatment, after doses of menotropins (GnRH?) were given.
lakerfan38
04-03-2012, 08:23 PM
hCG is very similar to LH.
Same alpha subunit as LH and similar beta subuint
I understand that it's made early by the embryo and then syncytiotrophoblasts to keep the corpus luteum producing progesterone.
I guess I can't figure out why it would cause an LH surge.
This is in the setting of an anovulatory/infertile female seeking fertility treatment, after doses of menotropins (GnRH?) were given.
lookmanohands
04-03-2012, 08:25 PM
I understand that it's made early by the embryo and then syncytiotrophoblasts to keep the corpus luteum producing progesterone.
I guess I can't figure out why it would cause an LH surge.
This is in the setting of an anovulatory/infertile female seeking fertility treatment, after doses of menotropins (GnRH?) were given.
(here's what I think/remember): The infertile woman is probably lacking FSH and LH. The menotropins are probably acting like FSH to handle what FSH was supposed to do.
FSH, LH, TSH, and hCG share a common alpha subunit so hCG can simulate an LH surge if you spike it into her. I think it's actually replacing the LH surge, not causing an LH surge
medstud87
04-04-2012, 12:58 PM
hCG is very similar to LH.
Same alpha subunit as LH and similar beta subuint
^This. Basically hCG = LH w/ weak FSH and TSH (TSH can cross placenta--> maternal hyperthyroidism but unapparent because of estrogen increasing TBG). Produced by placenta in order to 'save' the corpus luteum --> production of estrogen/PROGESTERONE from ovaries and corpus luteum until 2nd trimester when placenta takes over. Is actually highest in concentration 2nd and 3rd trimester.
Key board style question I got from Kaplan... "When can ovaries be removed during pregnancy (I don't know why you'd want to remove them but whatever)?"
Ans: After 1st trimester because placenta takes over.