Originally Posted by MedPR

It will fold differently since the solution has changed. I always had a problem with these since secondary will change, but so will tertiary. Secondary is probably the answer though, correct?

You can think of the protein the same way as the lipid bilayer. It projects its non-polar parts to the non-polar solution, and its polar parts to the polar solution. So in the lipid environment, its non-polars are pointing out toward solution and polar inward away from solution and vice versa for an aqueous environment.