Another Errata in FA not corrected-- Sigh

HelpPleaseMD said:

pg 510. angiotensin II works on AT1 receptors to mediate constriction.

Best of Luck to everyone on the test tomorrow. I hope I don't freak out on the WTF questions

Click to expand...

It does. It sounds a little counter-intuitive, but there are AT1 and AT2 receptors (and probably others as well) for ATII-binding. The AT1 receptors mediate vasoconstriction. As far as the AT2 receptors are concerned, I had always heard these were less significant and not to worry about them, but I recall them having some role in fetal development. Therefore, if one gets a question on teratogenicity and ATII, he or she should go with AT2 receptor; if it's a question on vasoconstriction, he or she should go with AT1 receptor.

Pg. 477 FA mentions cholinesterase inhibitors as antidote for Phase II of succinylcholine blockade. That doesn't make sense to me. Is that an error?

Also, in the updated errata, they said to remove malignant hyperthermia as toxicity for inhaled anesthetics. A few of the inhaled anesthetics, halothane and nitrous oxide, can cause malignant hyperthermia and I remember Kaplan specifically stating that for halothane I think it was. Hmm.

It's also important to know where exactly in the synapse those AT1 receptors are located.

thecalccobra said:

Pg. 477 FA mentions cholinesterase inhibitors as antidote for Phase II of succinylcholine blockade. That doesn't make sense to me. Is that an error?

Also, in the updated errata, they said to remove malignant hyperthermia as toxicity for inhaled anesthetics. A few of the inhaled anesthetics, halothane and nitrous oxide, can cause malignant hyperthermia and I remember Kaplan specifically stating that for halothane I think it was. Hmm.

Click to expand...

Interesting. I think it's because these generally induce malignant hyperthermia when used with succinylcholine, but you're right, the -fluranes can cause it on their own.

MrBeauregard said:

It's also important to know where exactly in the synapse those AT1 receptors are located.

Click to expand...

Could you please elaborate on that statement?

Selling my FA 2012 after Step I exam, had enough of all the errors...

Phloston said:

Could you please elaborate on that statement?

Click to expand...

AT1 receptors are presynaptic receptors.