- Joined
- Jul 6, 2005
- Messages
- 1,062
- Reaction score
- 156
there was never a study that showed clincally significant damage in humans from low flow Sevo regardless of the duratiuon.
fyi...
In three studies in human volunteers and one in surgical patients, prolonged (8-hour) sevoflurane exposures and low fresh gas flow rates resulted in significant exposures to compound A. Transient abnormalities were found in biochemical markers of renal injury measured in urine. These studies suggested that sevoflurane can result in renal toxicity, mediated by compound A, under specific circumstances.
....
Therefore, the United States Food and Drug Administration recommends the use of sevoflurane with fresh gas flow rates at least 1 L/min for exposures up to 1 hour and at least 2 L/min for exposures greater than 1 hour.
http://www.ingentaconnect.com/content/adis/dgs/2001/00000061/00000015/art00001
... and...
Although data from controlled clinical studies at low flow rates are limited, findings taken from patient and animal studies suggest that there is a potential for renal injury which is presumed due to Compound A. Animal and human studies demonstrate that sevoflurane administered for more than 2 MAC×hours and at fresh gas flow rates of < 2 L/min may be associated with proteinuria and glycosuria.
http://www.rxlist.com/cgi/generic2/sevoflurane_wcp.htm
remember, lawyers aren't concerned with what you think is "clinically significant" damage. if something happens to that kidney - whether it's really your fault or not - they're going to tell the jury that you should've known better.