Your welcome.
The POCD issue is also of interest to me as a neuroscientist, I thought I would provide this since it was brought up. I do think there is some form of POCD following GA but there is scant data.
Silverstein et al. (2007)
Central nervous system dysfunction after noncardiac surgery and anesthesia in the elderly.
Regional versus General Anesthesia
It is intuitively appealing that general anesthesia, which specifically affects the brain, as compared with regional anesthesia, which affects primarily the spinal cord or peripheral nerves, would be associated with different rates of POCD. Beginning in 1980, a series of relatively small studies suggested that patients undergoing general anesthesia, but not neuraxial anesthesia, were at greater risk for POCD.
34 In 1995, Williams-Russo et al.
39 presented an adequately powered, prospective, randomized study of POCD that used standard neuropsychological instruments. This study compared the effect of epidural versus general anesthesia on the incidence of POCD in patients undergoing elective unilateral total knee replacement. Neurocognitive assessment was performed 1–7 days preoperatively (n = 262) and 1 week and 6 months (n = 231) postoperatively. Group mean scores for each of the 10 measures were compared between the two anesthesia groups, but no statistically significant differences were observed postoperatively. In addition, the proportions of patients exhibiting clinically important decrements for each test (defined by consensus) were compared. Overall, 5% of patients exhibited a decline in cognitive function 6 months after surgery, but no statistically significant differences were found between the anesthesia groups. As this was a comparative trial, there was no control group for reference. Recently, Wu et al.
34 provided a comprehensive review of 24 studies that evaluated the choice of anesthesia and concluded that it does not influence the incidence of POCD.