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05-01-2012, 08:28 PM
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#1 |
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Senior Member
Join Date: May 2009
Posts: 419
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Grignards and carboxylic acids?
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But i was wondering what happens when it encounters a CA. Does it create a geminal diol? Or just snatch the H and become protonated? |
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05-01-2012, 08:30 PM
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#2 |
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Senior Member
Join Date: May 2009
Posts: 419
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Also, for grigs +esters
Why does grig knock off OR- but not the final OH-? I thought OR- had a much lower Pkb number than OH- |
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05-02-2012, 09:24 AM
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#3 |
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go nads go!
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the grignard makes a carboxylate in the first step, which is then protonated by acid in the second step. Second step only occurs after the grignard reagent is out of the picture.
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05-02-2012, 11:06 AM
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#4 |
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Senior Member
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So, just like an amine attacking the carboxylic acid,
Grignard just takes the H off the Carboxylic acid... |
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05-03-2012, 02:03 PM
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#5 | |
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8-16-13-39-42-45
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Quote:
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