High Yield "Minutia" Thread for STEP 1 !!!!

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chandler742

chandler742

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Let's post, high yield minutia that you have seen from your studies, or after you have taken the exam (DON'T SPECIFY WHAT SOURCE). Just give us a short sentence. I'll go first.

1. People who consume goat's milk = Vitamin B6 deficiency
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1. People who consume goat's milk = Vitamin B6 deficiency
2. Mid 40's Obese Woman = Cholelithiasis
3. Oral Glucose = "Ph"aster Insulin Release
 
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chandler742 said:
Let's post, high yield minutia that you have seen from your studies, or after you have taken the exam (DON'T SPECIFY WHAT SOURCE). Just give us a short sentence. I'll go first.

1. People who consume goat's milk = Vitamin B6 deficiency
Click to expand...

ok, you gotta explain this one to me, i thought that people who consumed unpasturized milk were at risk for brucelliosis (sp?) or even listeria.
 
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Tea and Toast diet--Vitamin C deficiency
Long term broad spectrum antibiotic use--clotting deficiency
Neuro defects on INH--Vit B6 deficiencfy
 
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Members don't see this ad :)
1)Clostridium difficile(spelling) Psueudomembranous colitis
Rx with Metronidazole(most cost effective) 2nd PO Vancomycin
2)Posterior cord brachial plexus Axillary n. for abduction
Radial n. for extension
3)Carbidopa and Levadopa combined because carbidopa is a
dopamine decarboxylase inhibitor doesnt cross BBB,diminishes
the metabolism of levodopa in peripheral tissues and increases the
availability of levodopa in the CNS.
 
Upvote 0 Downvote
Pellagra: diarrhea, dermatitis, dementia, death; caused by niacin (vit B3 deficiency).

What other 2 diseases can present w/ pellagra-like symptoms?? (scroll down)

















Hartnup's disease and Carcinoid syndrome...

Remember endogenous NAD+ (related to niacin) is generated from trp catabolism. If dietary trp resorption is impaired (Hartnup's dz) or if trp is being shunt toward other catabolites (Carcinoid syndrome --> xs 5-HT), then you'll get sxs of niacin deficiency.
 
Upvote 0 Downvote
Chloroquine is ONLY a blood schizonticide (inhibits malarial heme polymerase)
**watch out for G6PD, toxic psychosis,ocular toxicity* commonly used with
tissue schizonticide Primaquine because of liver latent P.ovale and vivax,these forms could absolutely be seen in the U.S.
 
Upvote 0 Downvote
chandler742 said:
Let's post, high yield minutia that you have seen from your studies, or after you have taken the exam (DON'T SPECIFY WHAT SOURCE). Just give us a short sentence. I'll go first.

1. People who consume goat's milk = Vitamin B6 deficiency
Click to expand...

Sorry, this is wrong. There is more B6 in goats milk than cows milk. Goats milk is deficient in B12/folate, most notably.
 
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a case of cystic fibrosis will also have :
eye/visual probs (vit A def)
hypocalcemia/bone prbs (vit D)
bleeding issues (vit K)
all kinds of nerve damage incl retinopathy, muscular degeneration, INCREACE IN LIPOFUSCIN CAUSING BROWN BOWEL SYNDROME
and hemolytic anemia and edema (all vit E)

i got caught on most of these so enjoy
 
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A man who recently had an MI is started on warfarin therapy. 3 months later, he has been working out, dieting, and taking vitamin supplements, but he feels weak and looks pale. His INR is found to be three times the standard interval, and he shows characteristics of iron-deficienct anemia. What vitamin has he taken too much of?











Vitamin E - inhibits the liver synthesis of the vitamin K-dependent factors (II, VII, IX, X). Effectively intensifies the action of warfarin.
 
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Looks like we have 2 RIGHT answers!! Thanks Idiopathic for the astute catch. I did some research and you are absolutely right.

The correct answer is B6 and Folate deficiency.

The Folate deficiency from Goat's milk could lead to Megaloblastic Anemia. This is known as Goat's Milk Anemia.

Take a look at Table 4, it shows that folate levels and B6 have much lower levels in goat's milk compared to cow's milk.

http://drinc.ucdavis.edu/html/milkg/milkg-1.shtml

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7083720

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Link&db=PubMed&dbFrom=PubMed&from_uid=14692912

Clin Pediatr (Phila). 1982 Aug;21(8):494-5. Related Articles, Links


Powdered goat's milk: pyridoxine deficiency and status epilepticus.

Johnson GM.

Publication Types:
Case Reports

PMID: 7083720 [PubMed - indexed for MEDLINE]



Idiopathic said:
Sorry, this is wrong. There is more B6 in goats milk than cows milk. Goats milk is deficient in B12/folate, most notably.
Click to expand...
 
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Members don't see this ad :)
chandler742 said:
Looks like we have 2 RIGHT answers!! Thanks Idiopathic for the astute catch. I did some research and you are absolutely right.

The correct answer is B6 and Folate deficiency.

The Folate deficiency from Goat's milk could lead to Megaloblastic Anemia. This is known as Goat's Milk Anemia.

Take a look at Table 4, it shows that folate levels and B6 have much lower levels in goat's milk compared to cow's milk. [/B]
Click to expand...


B12 and maybe folate are the key. I believe B6 is low yield, whereas if you see an infant on goats milk, 99/100 will have megaloblastic anemia.
 
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mjl1717 said:
Meigs syndrome - ovarian fibroma ,ascites and R. pleural effusion- important cause it can mimick ovarian Ca!
Click to expand...

Nobody can explain why it is a R-sided pleural effusion, either!! Technically it is CA, but it is 100% responsive to radiation.
 
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Given by my Kaplan Path professor. Which one has more Folate, Beer or Goat's milk? The answer is beer.

So the best way to get dietary folate for Pregnant mothers is Beer!!!!


Actually, I am prety sure it is green leafy veggies.

Dom
MSII NSU-COM, soon to be MSIII LSU-NO
 
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A diet with zero fat intake will lead to Vitamin A deficiency (pt presents w/ visual prob's).
 
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DrMaryC said:
A diet with zero fat intake will lead to Vitamin A deficiency (pt presents w/ visual prob's).
Click to expand...

Wouldn't a diet with zero fat intake also lead to deficiencies in Vitamins DEK too...i.e. deficiencies in all fat soluble vitamins?
 
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FoxyDoc said:
Wouldn't a diet with zero fat intake also lead to deficiencies in Vitamins DEK too...i.e. deficiencies in all fat soluble vitamins?
Click to expand...


Well I think Vitamin E and D would also quickly deficient but Vitamin K is produced by our intestinal "normal" flora, this is the basis of infant hemorrhagic disorder. So I would assume you might become deficient of vitamin K much later on if you were on a no fat diet.
 
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It was just a minutia statement, minutia-ites. It was a q bank or some other test question I had.

Vitamin A. :idea:
 
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Collecting what we have so far...

1. People drink goat's milk = Folate/B12 deficiency(Megaloblastic Anemia).
2. Mid 40's Obese Woman = Cholelithiasis
3. Oral Glucose = "Ph"aster Insulin Release
4. Tea and Toast diet--Vitamin C deficiency
5. Long term broad spectrum antibiotic use--clotting deficiency
6. Neuro defects on INH--Vit B6 deficiencfy
7. Clostridium difficile(spelling) Psueudomembranous colitis
Rx with Metronidazole(most cost effective) 2nd PO Vancomycin
8. Posterior cord brachial plexus Axillary n. for abduction
Radial n. for extension
9. Carbidopa and Levadopa combined because carbidopa is a
dopamine decarboxylase inhibitor doesnt cross BBB,diminishes
metabolism of levodopa in peripheral tissues and increases the
availability of levodopa in the CNS.

10. Pellagra: diarrhea, dermatitis, dementia, death; caused by niacin
(vit B3 deficiency).
11. Hartnup's disease and Carcinoid syndrome...
Remember endogenous NAD+ (related to niacin) is generated from trp
catabolism. If dietary trp resorption is impaired (Hartnup's dz) or if trp is
being shunt toward other catabolites (Carcinoid syndrome --> xs 5-HT),
then you'll get sxs of niacin deficiency
12. Chloroquine is ONLY a blood schizonticide (inhibits malarial heme
polymerase)

**watch out for G6PD, toxic psychosis,ocular toxicity* commonly used with
tissue schizonticide Primaquine because of liver latent P.ovale and vivax,these forms could absolutely be seen in the US

13. Vitamin deficiency associated with pheochromocytoma? Vitamin C, which aids in catalyzing dopamine-->norepi

14. a case of cystic fibrosis will also have :
eye/visual probs (vit A def)
hypocalcemia/bone prbs (vit D)
bleeding issues (vit K)
all kinds of nerve damage incl retinopathy, muscular degeneration,
INCREACE IN LIPOFUSCIN CAUSING BROWN BOWEL SYNDROME
and hemolytic anemia and edema (all vit E
15.A man who recently had an MI is started on warfarin therapy. 3 months later, he has been working out, dieting, and taking vitamin supplements, but he feels weak and looks pale. His INR is found to be three times the standard interval, and he shows characteristics of iron-deficienct anemia. What vitamin has he taken too much of?

Vitamin E - inhibits the liver synthesis of the vitamin K-dependent factors (II, VII, IX, X). Effectively intensifies the action of warfarin.

16. Meigs syndrome - ovarian fibroma ,ascites and R. pleural effusion- important cause it can mimick ovarian Ca

17. A diet with zero fat intake will lead to Vitamin A deficiency (pt presents w/ visual prob's).

18. Zinc Deficiency = Inability to smell and/or taste
19. Fat Digestion begins in stomach via lingual lipase(released in mouth)
20. Oral glucose activates Gastric Inhibitory peptide. GIP activates insulin
secretion.
21. Hydralazine = Systemic Lupus erythematosus
22. Oat Cell Carcinoma = Smokers = ectopic ACTH
23. Factory Worker = microcyic anemia, excess fatigue
24. Asthma = Restrictive Airway Disease
25. 6-10 month old baby crying = Stranger Anxiety
26. Reineke's crystalloids = Leydig Cell Carcinoma
27. Gardeners, Field workers = Organophosphate poisioning (ACH estase
inhibition)- irreversible noncompetitive
28. Alpha Thallesemia = Asians
29. Korsakoff's syndrome = alcohol, vitamin B1 deficiency, short term memory
loss
30. Ab Diversity = DNA rearrangement
31. Fasting individual drinks alcohol, becomes comatose = hypoglycemia
32. Trinucleotide repeats, anticipation to future generations = Huntington's
disease
33. Diphtheria toxin = EF2 inactivation (KNOW common toxins in translation)
34. Cystic Fibrosis = Pancreatic deficiency, oily stools, serum lipase&amylase
35. Paradoxic urine = metaoblic alkalosis (pH of urine is acidic)
 
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adding....

1. People drink goat's milk = Folate/B12 deficiency(Megaloblastic Anemia).
2. Mid 40's Obese Woman = Cholelithiasis
3. Oral Glucose = "Ph"aster Insulin Release
4. Tea and Toast diet--Vitamin C deficiency
5. Long term broad spectrum antibiotic use--clotting deficiency
6. Neuro defects on INH--Vit B6 deficiencfy
7. Clostridium difficile(spelling) Psueudomembranous colitis
Rx with Metronidazole(most cost effective) 2nd PO Vancomycin
8. Posterior cord brachial plexus Axillary n. for abduction
Radial n. for extension
9. Carbidopa and Levadopa combined because carbidopa is a
dopamine decarboxylase inhibitor doesnt cross BBB,diminishes
metabolism of levodopa in peripheral tissues and increases the
availability of levodopa in the CNS.

10. Pellagra: diarrhea, dermatitis, dementia, death; caused by niacin
(vit B3 deficiency).
11. Hartnup's disease and Carcinoid syndrome...
Remember endogenous NAD+ (related to niacin) is generated from trp
catabolism. If dietary trp resorption is impaired (Hartnup's dz) or if trp is
being shunt toward other catabolites (Carcinoid syndrome --> xs 5-HT),
then you'll get sxs of niacin deficiency
12. Chloroquine is ONLY a blood schizonticide (inhibits malarial heme
polymerase)

**watch out for G6PD, toxic psychosis,ocular toxicity* commonly used with
tissue schizonticide Primaquine because of liver latent P.ovale and vivax,these forms could absolutely be seen in the US

13. Vitamin deficiency associated with pheochromocytoma? Vitamin C, which aids in catalyzing dopamine-->norepi

14. a case of cystic fibrosis will also have :
eye/visual probs (vit A def)
hypocalcemia/bone prbs (vit D)
bleeding issues (vit K)
all kinds of nerve damage incl retinopathy, muscular degeneration,
INCREACE IN LIPOFUSCIN CAUSING BROWN BOWEL SYNDROME
and hemolytic anemia and edema (all vit E
15.A man who recently had an MI is started on warfarin therapy. 3 months later, he has been working out, dieting, and taking vitamin supplements, but he feels weak and looks pale. His INR is found to be three times the standard interval, and he shows characteristics of iron-deficienct anemia. What vitamin has he taken too much of?

Vitamin E - inhibits the liver synthesis of the vitamin K-dependent factors (II, VII, IX, X). Effectively intensifies the action of warfarin.

16. Meigs syndrome - ovarian fibroma ,ascites and R. pleural effusion- important cause it can mimick ovarian Ca

17. A diet with zero fat intake will lead to Vitamin A deficiency (pt presents w/ visual prob's).

18. Zinc Deficiency = Inability to smell and/or taste
19. Fat Digestion begins in stomach via lingual lipase(released in mouth)
20. Oral glucose activates Gastric Inhibitory peptide. GIP activates insulin
secretion.
21. Hydralazine, Isoniazid, Procainamide, Penacillamine (HIPP) = Systemic Lupus erythematosus
22. Oat Cell Carcinoma = Smokers = ectopic ACTH
23. Factory Worker = microcyic anemia, excess fatigue
24. Asthma = Restrictive Airway Disease
25. 6-10 month old baby crying = Stranger Anxiety
26. Reineke's crystalloids = Leydig Cell Carcinoma
27. Gardeners, Field workers = Organophosphate poisioning (ACH estase
inhibition)- irreversible noncompetitive
28. Alpha Thallesemia = Asians
29. Korsakoff's syndrome = alcohol, vitamin B1 deficiency, short term memory
loss
30. Ab Diversity = DNA rearrangement
31. Fasting individual drinks alcohol, becomes comatose = hypoglycemia
32. Trinucleotide repeats, anticipation to future generations = Huntington's
disease, Fragile X, Frederich's Ataxia, Myotonic Dystrophy
33. Diphtheria toxin = EF2 inactivation (KNOW common toxins in translation)
34. Cystic Fibrosis = Pancreatic deficiency, oily stools, serum lipase&amylase, high chloride sweat test
35. Paradoxic urine = metaoblic alkalosis (pH of urine is acidic)

36.What resembles G6PD but IS NOT X linked?
pyruvate kinase deficiency

37. Gaucher's disease (glucocerebrosidase defncy) causes ERLENMEYER FLASK shaped femoral head on xray. accumulation of macrophages, corticomedullary osteonecrosis.
 
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fernj1975 said:
Well I think Vitamin E and D would also quickly deficient but Vitamin K is produced by our intestinal "normal" flora, this is the basis of infant hemorrhagic disorder. So I would assume you might become deficient of vitamin K much later on if you were on a no fat diet.
Click to expand...

The key is the absorption. Even though it is part of the flora, the vitamin cant be absorbed without fat.
 
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imtiaz said:
24. Asthma = Restrictive Airway Disease
Click to expand...

I dont like this...asthma is a reactive airway disease, but has an obstructive pattern of disease. This is not a classic restrictive disease like sarcoidosis or interstitial fibrosis, but, rather, is due to air trapping and increased compliance (similar to emphysema). I am sure that everyone already knew this anyway, but I just wanted to mention it.
 
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Few more......

Drugs causing Lupus=CHIMP
C=Chlorpromazine, H=Hydralizine, I=Isoniazid, M=Methyldopa, P=Procainamide

Beta Thalasemia Major=Target lesions (peripheral smear), "Crew cut" on Head X-ray

Aniline dye=Transitional Cell Carcinoma

Rose gardner=Sporothrix schenkii; KISS it--Potassium (K) Iodide for S. Schenkii

Periodic hypertension, tachy, sweaty=Pheochromocytoma (10% rule)

That's all for now......
 
Upvote 0 Downvote
1. People drink goat's milk = Folate/B12 deficiency(Megaloblastic Anemia).
2. Mid 40's Obese Woman = Cholelithiasis
3. Oral Glucose = "Ph"aster Insulin Release
4. Tea and Toast diet--Vitamin C deficiency
5. Long term broad spectrum antibiotic use--clotting deficiency
6. Neuro defects on INH--Vit B6 deficiencfy
7. Clostridium difficile(spelling) Psueudomembranous colitis
Rx with Metronidazole(most cost effective) 2nd PO Vancomycin
8. Posterior cord brachial plexus Axillary n. for abduction
Radial n. for extension
9. Carbidopa and Levadopa combined because carbidopa is a
dopamine decarboxylase inhibitor doesnt cross BBB,diminishes
metabolism of levodopa in peripheral tissues and increases the
availability of levodopa in the CNS.

10. Pellagra: diarrhea, dermatitis, dementia, death; caused by niacin
(vit B3 deficiency).
11. Hartnup's disease and Carcinoid syndrome...
Remember endogenous NAD+ (related to niacin) is generated from trp
catabolism. If dietary trp resorption is impaired (Hartnup's dz) or if trp is
being shunt toward other catabolites (Carcinoid syndrome --> xs 5-HT),
then you'll get sxs of niacin deficiency
12. Chloroquine is ONLY a blood schizonticide (inhibits malarial heme
polymerase)

**watch out for G6PD, toxic psychosis,ocular toxicity* commonly used with
tissue schizonticide Primaquine because of liver latent P.ovale and vivax,these forms could absolutely be seen in the US

13. Vitamin deficiency associated with pheochromocytoma? Vitamin C, which aids in catalyzing dopamine-->norepi

14. a case of cystic fibrosis will also have :
eye/visual probs (vit A def)
hypocalcemia/bone prbs (vit D)
bleeding issues (vit K)
all kinds of nerve damage incl retinopathy, muscular degeneration,
INCREACE IN LIPOFUSCIN CAUSING BROWN BOWEL SYNDROME
and hemolytic anemia and edema (all vit E
15.A man who recently had an MI is started on warfarin therapy. 3 months later, he has been working out, dieting, and taking vitamin supplements, but he feels weak and looks pale. His INR is found to be three times the standard interval, and he shows characteristics of iron-deficienct anemia. What vitamin has he taken too much of?

Vitamin E - inhibits the liver synthesis of the vitamin K-dependent factors (II, VII, IX, X). Effectively intensifies the action of warfarin.

16. Meigs syndrome - ovarian fibroma ,ascites and R. pleural effusion- important cause it can mimick ovarian Ca

17. A diet with zero fat intake will lead to Vitamin A deficiency (pt presents w/ visual prob's).

18. Zinc Deficiency = Inability to smell and/or taste
19. Fat Digestion begins in stomach via lingual lipase(released in mouth)
20. Oral glucose activates Gastric Inhibitory peptide. GIP activates insulin
secretion.
21. Hydralazine, Isoniazid, Procainamide, Penacillamine (HIPP) = Systemic Lupus erythematosus
22. Oat Cell Carcinoma = Smokers = ectopic ACTH
23. Factory Worker = microcyic anemia, excess fatigue
24. Asthma = Restrictive Airway Disease
25. 6-10 month old baby crying = Stranger Anxiety
26. Reineke's crystalloids = Leydig Cell Carcinoma
27. Gardeners, Field workers = Organophosphate poisioning (ACH estase
inhibition)- irreversible noncompetitive
28. Alpha Thallesemia = Asians
29. Korsakoff's syndrome = alcohol, vitamin B1 deficiency, short term memory
loss
30. Ab Diversity = DNA rearrangement
31. Fasting individual drinks alcohol, becomes comatose = hypoglycemia
32. Trinucleotide repeats, anticipation to future generations = Huntington's
disease, Fragile X, Frederich's Ataxia, Myotonic Dystrophy
33. Diphtheria toxin = EF2 inactivation (KNOW common toxins in translation)
34. Cystic Fibrosis = Pancreatic deficiency, oily stools, serum lipase&amylase, high chloride sweat test
35. Paradoxic urine = metaoblic alkalosis (pH of urine is acidic)

36.What resembles G6PD but IS NOT X linked?
pyruvate kinase deficiency

37. Gaucher's disease (glucocerebrosidase defncy) causes ERLENMEYER FLASK shaped femoral head on xray. accumulation of macrophages, corticomedullary osteonecrosis.
38. Drugs causing Lupus=CHIMP
C=Chlorpromazine, H=Hydralizine, I=Isoniazid, M=Methyldopa, P=Procainamide
39. Beta Thalasemia Major=Target lesions (peripheral smear), "Crew cut" on Head X-ray
40.Aniline dye=Transitional Cell Carcinoma
41. Rose gardner=Sporothrix schenkii; KISS it--Potassium (K) Iodide for S. Schenkii
42. Periodic hypertension, tachy, sweaty=Pheochromocytoma (10% rule)
 
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drchris33 said:
Few more......

Rose gardner=Sporothrix schenkii; KISS it--Potassium (K) Iodide for S. Schenkii

That's all for now......
Click to expand...


I just had a question for Sporotrix on Q-bank...DOC is Itraconazole. I thought KOH also (as per micro ridic simple), but it wasn't among the answer choices :confused:
 
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You are correct......S.schenkii can be treated with either itraconazole or potassium iodide :thumbup: :thumbup:

Clinical Micro book rocks!
 
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BrooklynDO said:
39. Beta Thalasemia Major=Target lesions (peripheral smear), "Crew cut" on Head X-ray
Click to expand...


Careful here. "crew cut" can also be a presentation of sickle cell anemia. I had a question about this. Don't get caught on this Buzzword!
 
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BrooklynDO said:
hey i was also under the imperssion that a "erlermeyer flask like deformity"
is also pathmagnamonic for something else, but cant seem to find it....
anyone else care to chirp in?
Click to expand...

Osteopetrosis..too much deposition at metaphyisis..also known as marble bone dz.
 
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BrooklynDO said:
33. Diphtheria toxin = EF2 inactivation (KNOW common toxins in translation)
Click to expand...


Name the other toxin that inactivates EF2.....
 
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AlexRusso said:
Careful here. "crew cut" can also be a presentation of sickle cell anemia. I had a question about this. Don't get caught on this Buzzword!
Click to expand...

Thanks...I too had a question on this. Sickle cell was one of the answer choices and Beta Thal wasn't. But you are right on!
 
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On the jugular venous pulse

c-wave-S1, tricuspid closed,bulging of tricuspic iinto atrium (twisting of the
ventricles after AV valve opens)

v-wave systole, *filling of R.atrium, terminates when tricuspid valve opens,
beginning of S2
 
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Jarish-Herxheimer Rxn: flulike reaction (fever, chills, myalgias, tachypnea, tachycardia, & incr WBCs) within 2 hours of a Penicillin G treatment for syphillis
 
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mjl1717 said:
On the jugular venous pulse

c-wave-S1, tricuspid closed,bulging of tricuspic iinto atrium (twisting of the
ventricles after AV valve opens)
Click to expand...


I think you meant "twisting of the ventricles after the aortic and pulmonic valves open" The AV valves are closed at this point as this is the begining of systole and the S1 sound you mention is the closing of the AV valves.
 
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COLLECTING AGAIN!!! High Yield INFO

Let's keep Posting to help out fellow SDNers studying for Step 1!!!




1. People drink goat's milk = Folate/B12 deficiency(Megaloblastic Anemia).
2. Mid 40's Obese Woman = Cholelithiasis
3. Oral Glucose = "Ph"aster Insulin Release
4. Tea and Toast diet--Vitamin C deficiency
5. Long term broad spectrum antibiotic use--clotting deficiency
6. Neuro defects on INH--Vit B6 deficiencfy
7. Clostridium difficile(spelling) Psueudomembranous colitis
Rx with Metronidazole(most cost effective) 2nd PO Vancomycin
8. Posterior cord brachial plexus Axillary n. for abduction
Radial n. for extension
9. Carbidopa and Levadopa combined because carbidopa is a
dopamine decarboxylase inhibitor doesnt cross BBB,diminishes
metabolism of levodopa in peripheral tissues and increases the
availability of levodopa in the CNS.

10. Pellagra: diarrhea, dermatitis, dementia, death; caused by niacin
(vit B3 deficiency).
11. Hartnup's disease and Carcinoid syndrome...
Remember endogenous NAD+ (related to niacin) is generated from trp
catabolism. If dietary trp resorption is impaired (Hartnup's dz) or if trp is
being shunt toward other catabolites (Carcinoid syndrome --> xs 5-HT),
then you'll get sxs of niacin deficiency
12. Chloroquine is ONLY a blood schizonticide (inhibits malarial heme
polymerase)

**watch out for G6PD, toxic psychosis,ocular toxicity* commonly used with
tissue schizonticide Primaquine because of liver latent P.ovale and vivax,these forms could absolutely be seen in the US

13. Vitamin deficiency associated with pheochromocytoma? Vitamin C, which aids in catalyzing dopamine-->norepi

14. a case of cystic fibrosis will also have :
eye/visual probs (vit A def)
hypocalcemia/bone prbs (vit D)
bleeding issues (vit K)
all kinds of nerve damage incl retinopathy, muscular degeneration,
INCREACE IN LIPOFUSCIN CAUSING BROWN BOWEL SYNDROME
and hemolytic anemia and edema (all vit E
15.A man who recently had an MI is started on warfarin therapy. 3 months later, he has been working out, dieting, and taking vitamin supplements, but he feels weak and looks pale. His INR is found to be three times the standard interval, and he shows characteristics of iron-deficienct anemia. What vitamin has he taken too much of?

Vitamin E - inhibits the liver synthesis of the vitamin K-dependent factors (II, VII, IX, X). Effectively intensifies the action of warfarin.

16. Meigs syndrome - ovarian fibroma ,ascites and R. pleural effusion- important cause it can mimick ovarian Ca

17. A diet with zero fat intake will lead to Vitamin A deficiency (pt presents w/ visual prob's).

18. Zinc Deficiency = Inability to smell and/or taste
19. Fat Digestion begins in stomach via lingual lipase(released in mouth)
20. Oral glucose activates Gastric Inhibitory peptide. GIP activates insulin
secretion.
21. Hydralazine, Isoniazid, Procainamide, Penacillamine (HIPP) = Systemic Lupus erythematosus
22. Oat Cell Carcinoma = Smokers = ectopic ACTH
23. Factory Worker = microcyic anemia, excess fatigue
24. Asthma, sarcoidosis or interstitial fibrosis = Restrictive Airway Disease
25. 6-10 month old baby crying = Stranger Anxiety
26. Reineke's crystalloids = Leydig Cell Carcinoma
27. Gardeners, Field workers = Organophosphate poisioning (ACH estase
inhibition)- irreversible noncompetitive
28. Alpha Thallesemia = Asians
29. Korsakoff's syndrome = alcohol, vitamin B1 deficiency, short term memory
loss
30. Ab Diversity = DNA rearrangement
31. Fasting individual drinks alcohol, becomes comatose = hypoglycemia
32. Trinucleotide repeats, anticipation to future generations = Huntington's
disease, Fragile X, Frederich's Ataxia, Myotonic Dystrophy
33. Diphtheria toxin = EF2 inactivation (KNOW common toxins in translation)
34. Cystic Fibrosis = Pancreatic deficiency, oily stools, serum lipase&amylase, high chloride sweat test
35. Paradoxic urine = metaoblic alkalosis (pH of urine is acidic)

36.What resembles G6PD but IS NOT X linked?
pyruvate kinase deficiency

37. Gaucher's disease (glucocerebrosidase defncy) causes ERLENMEYER FLASK shaped femoral head on xray. accumulation of macrophages, corticomedullary osteonecrosis.
38. Drugs causing Lupus=CHIMP
C=Chlorpromazine, H=Hydralizine, I=Isoniazid, M=Methyldopa, P=Procainamide
39. Beta Thalasemia Major=Target lesions (peripheral smear), "Crew cut" on Head X-ray
40.Aniline dye=Transitional Cell Carcinoma
41. Rose gardner=Sporothrix schenkii; KISS it--Potassium (K) Iodide or itraconazole for S. Schenkii
42. Periodic hypertension, tachy, sweaty=Pheochromocytoma (10% rule)
43. Osteopetrosis..too much deposition at metaphyisis..also known as marble bone dz.
44. pseudomonas also ass. with Cystic Fibosis
45. On the jugular venous pulse
c-wave-S1, tricuspid closed,bulging of tricuspic iinto atrium (twisting of the ventricles after AV valve opens)
v-wave systole, *filling of R.atrium, terminates when tricuspid
valve opens,beginning of S2
46. Dimorphic Fungii = "Bad Hyphae Change Shape" = Blasto, Histo, Coccidio,
Sporothrix
47. Jarish-Herxheimer Rxn: flulike reaction (fever, chills, myalgias,
tachypnea, tachycardia, & incr WBCs) within 2 hours of a Penicillin G
treatment for syphillis
 
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Question.. What vitamin would be missing in a person who is a vegetarian and DOESNT eat milk and eggs and one that DOES eat milk & eggs. I had this question and I figured it was either B12 of Vitamin D. IN FA it lists both as sources of both.. WTF?
 
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These keep driving me crazy when I get a q on QBank, so I thought I would share:

HLA A3= Hemochromotosis
HLA DR2= SLE and Multiple sclerosis
HLA DR3= Type I Diabetes and SLE and Celiac Dz
HLA DR4= Type I Diabetes and Rheumatoid arthritis
 
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EctopicFetus said:
Question.. What vitamin would be missing in a person who is a vegetarian and DOESNT eat milk and eggs and one that DOES eat milk & eggs. I had this question and I figured it was either B12 of Vitamin D. IN FA it lists both as sources of both.. WTF?
Click to expand...

B12 is only found in animal products, I believe.
 
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vitamin A and vitamin D can have toxic overdose because they are fat soluble (can be stored) and have steroid-receptor mechanisms (zinc fingers). vit E 'toxicity' is via warfarin potentiation

vitamin A tox --> Arthralgia, Allopecia, Aching head (cerebral edema), Aching throat, and Apathy (well..fatigue, but i was on such a roll), and cirrhosis

vitamin D tox causes metastatic calcifications--can be associated with sarcoidosis. made in 3 steps at the skin --> liver --> kidney (PTH-25)

vitamin A toxicity doesn't bother the eyes because here it works at the outer rod segment via inhibitting cGMP (rhodopsin). a common source is a yummy yum fatty fat fat animal liver
 
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Bumping again for others out there like me - taking it tomorrow!
 
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DrMaryC said:
A diet with zero fat intake will lead to Vitamin A deficiency (pt presents w/ visual prob's).
Click to expand...

I couldn't believe it. I had a usmle question about some guy who had some sort of malabsorption situation ( I can't remember if it was drugs he was taking--like anti cholesterol or if it was his diet)

AND LO AND BEHOLD

one of the answer choices was loss of night vision. I chose it.

None of the other answers made sense.

GOOD LUCK!
 
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