Theophylline and Kinetics

[kristakoch]

Hi everybody~

I just wanted to get some info from you all out there who have already taken kinetics. I am doing a teaching rotation with my kinetics professor right now and we are looking at the material covered in the class.

One thing that seems to glare out at us is that we teach theophylline dosing, etc eventhough it is never really used anymore. I think it is a good example to show how to use all the kinects equations, but it does suck to have to learn it and then never see it again.

SO, my question to you all is, does your kinetics class go over theophylline anymore, and if yes, how do they present it. Or, is there some other drugs that your profs use in the class. Right now, we teach theophylline, procainamide, phenytion, digoxin, phenobarbital, VPA, lidocaine and then AMG and vanco.

Please let me know what else you guys learned about....immunosuppressants?, HIV drugs? etc?

Thanks

[baggywrinkle]

Originally Posted by kristakoch

Thanks

Theophylline kinetics are such an excellent example of a linear model, why wouldn't you want to at least be exposed to it? While theophylline might not be the workhorse it once was when I could go through 35 vials of aminophylline in a shift among an inpatient population of eighty patients,
you do still see it in "the real world".

I have not worked hospital in six years now but I can tell you that the oral theophylline preparations do still move in community settings albiet at a leisurely pace. There is still a need, so you still need to know. Heck, I dispensed reserpine for the first time in my career just last month. You talk about a tired old war horse. Quick, without looking, what classic tidbit of information is relevant about reserpine to a clinical pharmacist?

[ZpackSux]

Other than the oral form (theodur), we rarely dispense IV - aminophylline.

When I was in school, only immunosuppresant was cyclosporine..and only HIV med was AZT... and DDI..

[pharmpoke]

Heck, I dispensed reserpine for the first time in my career just last month. You talk about a tired old war horse. Quick, without looking, what classic tidbit of information is relevant about reserpine to a clinical pharmacist?[/QUOTE]

we got a call a couple weeks ago about reserpine overdose and everyone here was perplexed as to where the person even got it. then we found out it had come from another country. what's the answer to your riddle?

[GravyRPH]

Has anyone noticed Zpack really likes the smiley? I think there should be a daily use max allowed per smiley.

And agree with above. I don't think I've dispensed Amo once, but I keep ordering it in after the previous batch has expired.

Vanco and Gent are the key PK meds. Everything else just makes us sound smarter.

[baggywrinkle]

Originally Posted by GravyRPH

Vanco and Gent are the key PK meds. Everything else just makes us sound smarter.

Are tobramycin and amikacin dead also?

[baggywrinkle]

Originally Posted by pharmpoke

what's the answer to your riddle?

Depression

[lisi]

Originally Posted by baggywrinkle

Theophylline kinetics are such an excellent example of a linear model, why wouldn't you want to at least be exposed to it? While theophylline might not be the workhorse it once was when I could go through 35 vials of aminophylline in a shift among an inpatient population of eighty patients,
you do still see it in "the real world".

I have not worked hospital in six years now but I can tell you that the oral theophylline preparations do still move in community settings albiet at a leisurely pace. There is still a need, so you still need to know. Heck, I dispensed reserpine for the first time in my career just last month. You talk about a tired old war horse. Quick, without looking, what classic tidbit of information is relevant about reserpine to a clinical pharmacist?

The aminoglycosides are just as good an example of a linear model, if not better AND they are still used. Vanco and gent/tob are the key drugs to know the kinetics of. The only thing you need to remember about theophylline is how to convert a dosage to aminophylline--NAPLEX still pulls that one out every once in a while.

[GravyRPH]

Originally Posted by baggywrinkle

Are tobramycin and amikacin dead also?

Ooops, sorry, Meant to say Vanco and AMG's. We primarily use Gent at my hospital, but the others are alive and well.

[ZpackSux]

Originally Posted by GravyRPH

Has anyone noticed Zpack really likes the smiley? I think there should be a daily use max allowed per smiley.

And agree with above. I don't think I've dispensed Amo once, but I keep ordering it in after the previous batch has expired.

Vanco and Gent are the key PK meds. Everything else just makes us sound smarter.

Ok.. I see...

[ZpackSux]

Originally Posted by GravyRPH

Ooops, sorry, Meant to say Vanco and AMG's. We primarily use Gent at my hospital, but the others are alive and well.

Gent, Tobra, Vanc, and Amikacin... primary PK drugs.. Linear Kinetics

Nothing like Phenytoin and Michelis-Menton - non linear PK

[Caverject]

This thread gives me the willies

[dgroulx]

We had extensive theophyilline problems. They even brought in a guest lecturer/specialist.

We also covered aminoglycosides, vanco, lidocaine, procainamide, phenobarbital, carbamazapine, valproic acid, cyclosporin, tacrolimus, digoxin, methotrexate, phenytoin. There are probably some others that I missed.

[ultracet]

Originally Posted by dgroulx

We had extensive theophyilline problems. They even brought in a guest lecturer/specialist.

We also covered aminoglycosides, vanco, lidocaine, procainamide, phenobarbital, carbamazapine, valproic acid, cyclosporin, tacrolimus, digoxin, methotrexate, phenytoin. There are probably some others that I missed.

yeah us too

[kristakoch]

Thanks everybody for their replies. Looks like we will keep theophylline, at least it's a fairly easy drug to show how all of the CPK formulas work (and the fact that it can still show up on the NAPLEX ). Anyways, just wanted to give a large THANK YOU for all of the replies and the time you took to do them

[npage148]

Originally Posted by pharmpoke

Heck, I dispensed reserpine for the first time in my career just last month. You talk about a tired old war horse. Quick, without looking, what classic tidbit of information is relevant about reserpine to a clinical pharmacist?

Thats odd, i was looking yesterday and there was a bottle of it on the shelve. We must have gotten a script for it and ordered it when i was off for a few days. Maybe the reserpine drug rep is going around