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Please enlighten re: sexual dysfunctiuon vs SSRI's, SNRI's, TCAs, MAOI's, Wellbutrin, Remeron, Trazodone, Nefazodone.and Buspirone.
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I think it's a 5ht1a blocker like trazodone and buspar. Putatively, 1a agonism causes anorgasmia, so vilazodone should not have sexual side effects (and should block sexual side effects of other serotonergic drugs).
I think it's a 5ht1a blocker like trazodone and buspar. Putatively, 1a agonism causes anorgasmia, so vilazodone should not have sexual side effects (and should block sexual side effects of other serotonergic drugs).
Well, 5ht1a antagonistc and an SSRI. I just have yet to figure out the advantage to this v. an SSRI and buspirone other than not having to dose multiple times per day and perhaps the placebo effect of paying a lot more. I've never used vilazodone because I've had perfectly acceptable results with the SSRI-buspirone combo.
Well, 5ht1a antagonistc and an SSRI. I just have yet to figure out the advantage to this v. an SSRI and buspirone other than not having to dose multiple times per day and perhaps the placebo effect of paying a lot more. I've never used vilazodone because I've had perfectly acceptable results with the SSRI-buspirone combo.
I'm totally on board regarding cost and efficacy issues. However, I do think that it is significant if vilazodone has significantly less sexual dysfunction than standard SSRI's.
One issue with Viibryd that is not well known but I think may become HUGE is this issue of all known agonist of 5HT-2B in the nanomolar range causes cardiac valvulopathy in long term use. Bryan Roth's, one of the world leaders in psychiatric drugs development, wrote about this and gave a talk about this issue recently as well
http://circ.ahajournals.org/content/102/23/2836.full
http://circ.ahajournals.org/content/102/23/2836.full
This thread is a few months old, but I'd like to revisit it. Is anyone exited about using vilazodone? I have seen several folks struggle with headaches and GI effects.
Ran this by one of our big pharm researchers, who said Bryan Roth (the researcher mentioned him by name, not from me saying it) was just trying to get a lot of notoriety out of this but that there's nothing to it.
I have no clue, my source has never failed me, but who knows. In vitro vs in vivo, who knows. It's still a stupid medicine I won't prescribe until it's off patent, unless I learn otherwise.