Differential for gingival hypoplasia

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So in reviewing for step 1 I have come across Gingival HYPERplasia quite alot (phenytoin, Calcium blockers, cyclosporine, monocytic AML) but I came across Gingival HYPOplasia the other day on reviewing biochem.

I was just curios, what would be the differential if you came across it? Not much seems to be written about it when I google search.


PS I came across Gingival HYPOplasia as a symptom of I-cell disease

Because I just read your post and have no idea, I'll give a random tidbit instead:

Hypodontia refers to missing teeth, usually due to congenital impaction / anomaly.

This is in contrast to edentulism, which is the "acquired" loss of teeth, such as due to an accident.

I tend to get OCD about that for some reason (i.e. one of my classmates was doing a respiratory exam last year on a ~60M and mentioned "no hypodontia" when assessing the decreased probability of pulmonary abscess, when it should have been "no edentulism").

Cool, ill expand on that tidbit and add that odontoblasts are of neural crest cell origin.

Cheers, BTW my source for gingival hypoplasia in I cell disease is Lange Biochemistry & genetics flashcards.

Google searches only turn up gingival hyperplasia on I cell disease. Maybe a typo on Langes flash cards?

yep, definitely a typo. wonder if they pay out for catching mistakes like first aid does.

"In mucolipidosis II (I-cell disease), the most common of the mucolipidoses, there is usually an early onset of psychomotor retardation, but in some cases this does not appear until the second or third decade of life. Abnormal facies and periosteal thickening (dysostosis multiplex, like that of GM1 gangliosidosis and Hurler disease) are characteristic. Gingival hyperplasia is prominent, and the liver and spleen are enlarged; but deafness is not found and corneal opacities are slower to develop."

source: Adams and Victor's Neurology

Nothing causes gingival hypoplasia according to the disease database. Normally it's pretty exhaustive. Ex. if you want to drive yourself insane learning all the differential diagnosis of gingival hyperplasia...
http://www.diseasesdatabase.com/resu...nClassSort=255

Just encountered enamel hypoplasia as a side-effect in neonates of maternal-use of tetracyclines during pregnancy.

Tooth discoloration + enamel hypoplasia are characteristic!

This info is from UWorld question ID#: 1775.

How about osteogenesis imperfecta in relation to dentin?

Originally Posted by Phloston

Just encountered enamel hypoplasia as a side-effect in neonates of maternal-use of tetracyclines during pregnancy.

Tooth discoloration + enamel hypoplasia are characteristic!

This info is from UWorld question ID#: 1775.

btw, how are you liking uworld?

Originally Posted by RedSoxSuck

btw, how are you liking uworld?

I've only done three blocks so far (so my opinion doesn't really mean much yet), but honestly, I don't see why everyone says the QBank is such a big deal. The explanations I believe are what makes this QBank so good, but the questions themselves aren't written much differently or better than others I've encountered previously. I can also say that Kaplan has helped me for UWorld. I encountered primidone yesterday (18% answered correctly), for instance, but I had seen this in Kaplan already.

Originally Posted by Phloston

I encountered primidone yesterday (18% answered correctly), for instance, but I had seen this in Kaplan already.

Haha would you believe I just encountered the same question myself today. I could only vaguely remember having heard the name, but it was quite obvious from elimination, the rest blatantly being non barbiturates.

I've gotten a few questions correct on the QBanks because of this forum (probably like 5 total as a direct result).

However, I've also gotten a UWorld question wrong because of this forum.

Well luckily I did the question before I visited this thread.

But I wouldn't count it as cheating if you learned something from a thread and then encountered it as a question. Just like doing UWorld before you're "fully prepped" vs after, it's the fact that you've prepped well (knowledge + familiarity with questions) that helps you get your Step 1 score, not your UWorld % correct, it's merely a product of your preparation.

Originally Posted by Phloston

I've only done three blocks so far (so my opinion doesn't really mean much yet), but honestly, I don't see why everyone says the QBank is such a big deal. The explanations I believe are what makes this QBank so good, but the questions themselves aren't written much differently or better than others I've encountered previously. I can also say that Kaplan has helped me for UWorld. I encountered primidone yesterday (18% answered correctly), for instance, but I had seen this in Kaplan already.

I'm assuming you're averaging 82% + thus far?

I'm 85% through four blocks. However I'm taking that with a grain of salt because it probably just means I'll get four straight blocks of 70% later on at some point.