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In FA, it says that Liver disease, alcoholism, reticulocytosis, metabolic disorder, and drugs like 5FU, AZT, hydroxyurea can cause non megaloblastic macrocytic anemia.
I think those DNA synthesis inhibiting drugs as well as metabolic disorder such as orotic aciduria should probably cause megaloblastic anemia, no?
Also, I undersatnd that reticulocytosis would cause non-megaloblastic macrocytic anemia by just increasing the sheer number of reticulocytes.
But How does hypothyroidism, alcoholism and liver disease cause non-megaloblastic macrocytic anemia? Does anyone know the mech behind this?
I think those DNA synthesis inhibiting drugs as well as metabolic disorder such as orotic aciduria should probably cause megaloblastic anemia, no?
Also, I undersatnd that reticulocytosis would cause non-megaloblastic macrocytic anemia by just increasing the sheer number of reticulocytes.
But How does hypothyroidism, alcoholism and liver disease cause non-megaloblastic macrocytic anemia? Does anyone know the mech behind this?
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