I was asked to share some of my experiences from last year. What I'm posting is a combination of details both from my interview and from what I've gathered from other interviewees and classmates.
From the 2011-2012 thread: "I interviewed today, and it was a very good experience. The day starts with a brief presentation from Dr. Baker. Interviewees are divided into three groups; one interviewing at 9:00, one at 10:00, and one at 11:00. When you are not interviewing, you are being shown the modules and D2L or you are touring the simulation center. You will generally have 3 interviewers, and one is often a 4th year med student. My interviewers asked mostly about my extracurricular activities, with just one question regarding issues in healthcare. You'll hear it a thousand times, and it really is true: They're just trying to get to know you. So relax, be honest, and show them why you deserve to be there. Good luck!"
I would echo everything that the above poster said, except being asked about issues in healthcare. My interviewers were extremely laid back, and they focused mainly on extracurriculars, internships, and my interests--basically spending the majority of the time getting to know me and expanding on what I wrote on AMCAS. One of the interviewers was a physician from my hometown, so we talked about living there for a solid 5 minutes. Not once was I asked anything regarding ethics or current topics in medicine.
The only really medicine-themed questions they posed were "Tell me about yourself" (big money question) and "If you care about people so much, why not social work?" (their roundabout way of asking "why do you want to be a doctor?") One of the things I don't think has been mentioned is that the beginning of the interview is closed, meaning none of the interviewers know your GPA or MCAT scores. The only information available to them is your AMCAS activities section, plus that one-page application you submitted (name, undergraduate institution, major, etc). About halfway through the interview, they ask you to leave the room and stand in the hallway; during this time, they open the other half of your application materials and review your numbers. They didn't spend any time asking about my MCAT (maybe a brief "good job" comment), but asked me about why I got a C in one of my prereqs (Ochem I, the class from hell). Apparently my explanation sufficed because they didn't dwell on it at all, and it was back to the fun kind of questions.
People always say that OU's interview style is conversational, and there's not any other way to describe it. I asked my interviewers what they liked most about OU, what their specialties were (or in the case of the 4th year, what specialty she was hoping to match into), and why they chose those specialties. It was pretty easy to keep the conversation going, and apparently my interview was one of the longer ones, although I didn't notice because there weren't any lulls or awkward silences.
But user beware--my interview was definitely very lax in comparison to others. I talked to several people who
were asked about the Affordable Care Act, or healthcare in general. One girl was asked to name something like 3 discoveries that revolutionized medicine. Several people were given one or two ethical scenarios and asked what they would do. One guarantee is that if you have any sort of misdemeanor, you'll be asked about it in detail--case in point: a guy in my walking group was asked more about his MIP than himself, and when that was no longer interesting, his interviewers grilled him on ethical scenarios (think 4 or 5). Really, the quality of your interview depends on the people in the room with you, but for the most part, they're very easygoing. Remember, they're trying to sell OU to you just like you're trying to sell yourself.
At some point in my interview, I think I was also asked "Why OU?" To be honest, I'm sure they love hearing that you want end up in Oklahoma after residency. But don't just say that because you think it's what they want to hear--actually mean it. The goal of the university is to train physicians to practice in the state of Oklahoma, because they contribute an ungodly amount of money to your medical education. One of our professors told us that OU pays for approximately 75% of your med school tuition--which is a huge investment in the long run. So they're ultimately looking for people who see themselves in-state for the majority of their career. That being said, if you're an OOS applicant who just loves Sooner football or a longtime OK resident who can't wait to get out as soon as they graduate, more power to you. Just don't necessarily tell your interviewers that.
If you need help preparing or familiarizing yourself with interview questions in general, I would recommend the "Interview Feedback" portion of SDN. There were some great resources there that (while not necessarily a part of my interview) helped me gain somewhat of an idea of what to expect; similarly, the committee interview (for those of you who went to OU for undergrad) was extremely helpful in providing a feel for the panel interview.
TL;DR Know your AMCAS in detail, be prepared to answer questions about healthcare/ethics (SDN Interview Feedback is your best resource), and don't panic! Of all the schools I interviewed at, OU was by far the most conversational and least stressful. Have fun and good luck!