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One of the questions I did presented a clinical vignette of C. perfringens and asked what you would see from the debrided tissue under microscopy and the answer was the absence of neutrophils. But the solution did not really explain why? How come you get no neutrophils with C. perfringens? Can anyone explain this please? Thank you. Below is the explanation.
"Traumatic gas gangrene is a fulminant disease, typically caused by Clostridium perfringens type A and characterized by extensive tissue destruction rapidly progressing to shock and death. Muscle biopsy in clostridial gas gangrene reveals large Gram-positive rods with truncated ends and a striking paucity of leukocyte infiltration."
"Traumatic gas gangrene is a fulminant disease, typically caused by Clostridium perfringens type A and characterized by extensive tissue destruction rapidly progressing to shock and death. Muscle biopsy in clostridial gas gangrene reveals large Gram-positive rods with truncated ends and a striking paucity of leukocyte infiltration."