You will make more working in a non-academic setting, generally speaking. You will also likely see higher volumes of patients, be less connected with the research community, and have less of a teaching role (you might oversee PAs for instance). What's most appropriate depends on what you want out of a career. In my experience academic jobs tend more toward $150k or less starting but with good benefits, while non-academic jobs that appear comparable start a little over $200k, but as has already been said these numbers vary a great deal from place to place. I think in the midwest, Texas, South, and generally places that are underserved you can find academic salaries that are much better.