There's a really good article in CDEM from April 2014 on this very subject. I highly recommend reading it if anyone else is a subscriber. I have a PDF version that I would gladly post in here...if it didn't break forum policy. Ahem...
The key section of the article which we are all interested in "In which stable patients with AF is emergency department cardioversion safe?"
Here were a few takeaway points that I learned from the article.
- RACE and AFFIRM trials appear to at least give the rhythm control crowd a leg to stand on with the AFFIRM trial being the larger one by far.
- 30-45% of paroxysmal AF occurs in younger pt's without demonstrable underlying cardiac disease. (The only group I would personally consider cardioversion if they were hemodynamically stable. )
- It's worth figuring out WHY? the pt went into AF. Causes: Valvular heart disease, HTN, LVH, alcohol, surgery, MI, peri/myocarditis, PE, pulmonary disease, hyperthyroidism, metabolic derangements, the list goes on and on....
- AHA 2001 guidelines recommend cardioversion of AF with duration less than 48 hrs citing "low risk of thromboembolism". This recommendation has not been reaffirmed or refuted by the 2006 or 2011 AHA updates.
- Pt perception of duration of AF is NOT accurate. Studies revealed 68% accuracy is pt perception and 40% of pt's with newly diagnosed AF are asymptomatic. 58% of pt's with implanted rhythm control devices revealing AF were also asymptomatic. (So, essentially... a pt telling you "Doc, it's def been less than 48 hours means nothing.)
- There's a few studies on the specific complications...following both pharmacologic and electrical cardioversoin. Maisel and Stiel, etc.. Relatively small studies, but citing up to 11% complication rate. However, I found it interesting they they don't discuss the specific complications. Another study tried to clarify the complications and 6% suffered sedation complications, 2% suffered burns, VTach, unstable bradycardia.
- Risk of thromboembolism following cardioversion of AF without simultaneous anticoagulation is 0-7%
- 66% of "new onset" AF will spontaneously convert to normal sinus rhythm within 24 hours and this number increases to 80% by 48 hours.
- Atrial "kick" accounting for 10-15% boost in CO does not return for days to weeks following cardioversion 2/2 atrial myocardial stunning. (This is a reason for arguing in favor for 3-4 weeks anti-coagulation following cardioversion.) The "stunning" effect is noticed both in electrical, pharmacologic, and spontaneous cardioversion.
- Although new onset AF can be atypical presentation of ACS, incidence of ACS in pt's with new onset AF ranges from 1% - 11%
Myths:
- No stroke risk with cardioversion of acute AF within 48 hours of onset. (Study showed 143 pt's with TEE prior to cardioversion of AF < 48hrs with 14% atrial clot vs 27% in chronic AF.)
- No stroke risk associated with cardioversion preceded by a negative TEE . Study showed 6% risk of thromboembolic event following negative TEE. (Is TEE imperfect screen? Or... does the clot form 2/2 atrial stunning. Consensus seems to indicate that it's forming post cardioversion due to the stunning effect which makes a stronger argument for post cardioversion anti-coagulation.)
Who can be safely discharged?
- AF in stable pt with HR < 120 needs no emergent treatment according to the authors.
- AF related to temporary causes: alcohol, surgery, pericarditis, PE, myocarditis, hyperthyroidism, metbolic disorders, --> treat underlying condition and the AF will resolve.
- HF, MI, chest pain, hypotension, renal failure, PE, hyperthyroidism, etc.. --> obviously get admitted. Of note, pt's with "structural heart disease" should also be strongly considered according to authors.
Ottawa Aggressive Protocol is a separate discussion.
Summary:
The authors seem to encourage:
- Cardioversion for hemodynamically unstable pt's, which we already knew.
- Taking into consideration RACE and AFFIRM...choosing conservatively and opting for rate control seems to maximize pt safety with diltiazem as the ideal rate control agent in nearly all pt's except those with suspected ACS or thyroid disease.
- Data on the safety of ED cardioversion in "low-risk" pt's with known AF duration of less than 48 hours is accumulating but risk of thromboembolic events as well as non thrombotic complications and a 24hr spontaneous conversion rate of 66% (80% at 48hrs) must be considered when choosing rhythm control.
So, in essence, I feel in the same boat as the authors. There is certainly enough growing evidence for the use of aggressive cardioversion and d/c in the ED but I don't feel like all the data is there yet and it's certainly not standard of care and continues to be a hotly debated topic in need of more research over the next several years before I see it ever as adopted as mainstream practice.
The biggest issues for me are: 1) Complication risk and 2) Ruling out all the other important underlying contributing etiologies to the AF that might preclude or dissuade me from aggressive cardioversion. Valvular and structural heart disease along with masked ACS is on the top of my head. Hyperthyroidism? I mean, am I going to get a reflex TSH and echo an all my pt's prior to juicing the pads? (Of note, I'm still not going to see an atrial clot with the TTE as TEE is much more sensitive.) Young pt's with no medical conditions are one thing, but that makes up a very small percentage of the "new onset" AF that I seem to see at my shop.
Either way, I see any and all complications from this practice as big lawsuits, and with the dearth in relative number of convincing studies to make this mainstream practice, I would do my best to rule out all the underlying contributing etiologies mentioned in the supporting literature that might contraindicate aggressive cardioversion since if you are involved in a lawsuit, that's the literature you're going to be using to support your decisions. If you're going to be thorough in that endeavor, it really begs the question... are you saving any time in the ED? Again, for me... almost all of these even mildly complicated pt's are easy, easy admissions.
Interesting topic and very relevant. It's good to see everyone's practice patterns. I can honestly see both sides though I definitely lean more conservative in my approach. Good stuff.
Oh, grab that CDEM issue if you can. Very high yield. Every bullet point has a supporting journal article(s) but it was just too much to post. If you want a specific reference, just ask and I'll add it to the bottom of this post.