Sure it's possible! But if it'll work out is more of a case-by-case basis. I am only two weeks into school, but it's been OK so far for me; my girlfriend moved across the state with me and got a job about a month before school started. Her brother had recently gone through med school, and she saw how many hours of work went into that, so she knew what to expect with me. I'm in class while she's at work, and I study every night in our office, but we make time to eat and watch jeopardy together. We've tried to make one weekend night "closed book" and just focus on hanging out and enjoying each other's company. It works for us, may not work for you. Many of my classmates have LDRs, which personally I don't think I could maintain, but they seem to be OK so far. Hope this helps!