I'm going through the BR, and it emphasizes over and over again that Carboxylic acids can be converted to esters, anhydrides, and acid halides.
But it never mentions Amides.
I'm wondering why carboxylic acids cannot become amides.
NR2- is a much stronger base than OH-, hence I would think that regular attack on the carbonyl carbon should kick off the OH.
Unless there is something about OH that I am missing?
But it never mentions Amides.
I'm wondering why carboxylic acids cannot become amides.
NR2- is a much stronger base than OH-, hence I would think that regular attack on the carbonyl carbon should kick off the OH.
Unless there is something about OH that I am missing?