Can someone answer these two pharmacology questions?

[student12399]

Why do children get prednisolone and adults get prednisone?


Please give specific answers to each and any citations would be greatly appreciated!

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[njac]

Prednisolone tastes better than prednisone and there isn't alcohol in the liquid formulation of prednisolone.

 

[Rouelle]

Not to be that a-hole about trivial/unimportant details, but I think the Prelone formulations contain alcohol.

 

[zelman]

http://forums.studentdoctor.net/threads/nsaids-and-asthma-help.872766/

 

[zelman]

Not to be that a-hole about trivial/unimportant details, but I think the Prelone formulations contain alcohol.

Yeah. Prednisolone sodium phosphate formulations do not contain alcohol. Their response was inaccurate.

 

[HelpfulPharmer1]

2. Why do children get prednisolone and adults get prednisone?


Please give specific answers to each and any citations would be greatly appreciated!

Please note: infant UNDER 1 YEAR can get prednisone liquid.
But, because of bad taste, prednisone liquid is not preferred.
prednisolone liquid by brand name ORAPRED is ORALLY PREFERED (manufacturer made the name easy to remember)

Source: to prove that under 1 year old can take prednisone.
http://www.drugs.com/dosage/prednisone.html
Usual Pediatric Dose for Asthma
< I year:
acute: 10 mg orally every 12 hours.
maintenance: 10 mg orally very other day.

1 to 4 years:
acute: 20 mg orally every 12 hours.
maintenance: 20 mg orally every other day.

5 to 12 years:
acute: 30 mg orally every 12 hours.
maintenance: 30 mg orally every other day.

>12 years:
acute: 40 mg orally every 12 hours.
maintenance: 40 mg orally every other day.

http://www.drugs.com/dosage/prednisone.html

Current product:
Prednisone Oral solution
Prednisone 5mg/5ml Solution (00054-3722) (Roxane Laboratories Inc)

Prednisone 5mg/5ml Solution (00054-8722) (Roxane Laboratories Inc)

Prednisone Intensol 5mg/ml Solution (00054-3721) (Roxane Laboratories Inc)

**************
Now, the answer to your question:

2. Why do children get prednisolone and adults get prednisone?


Please give specific answers to each and any citations would be greatly appreciated!

Liquid often have bad taste. Orapred is prednisolone liquid that is less nasty and has less chance of vomiting.

Therefore, good guess is: doctors often give liquid prednisolone ORAPRED to children to reduce the chance of vomiting.

Source: http://www.ncbi.nlm.nih.gov/pubmed/16801838

Oral corticosteroids are an essential part of the management of children with acute asthma exacerbations. Vomiting is a frequently cited problem attributed to oral corticosteroids. A new formulation of prednisolone, Orapred, claims to have improved palatability that may decrease the incidence of vomiting.

CONCLUSIONS:
In our study population, Orapred was associated with a significant less incidence of vomiting and better taste score compared to the generic prednisolone.
Source: http://www.ncbi.nlm.nih.gov/pubmed/16801838

 

[HelpfulPharmer1]

1. Why are NSAIDs and naproxen not recommended with asthma patients?

2. Why do children get prednisolone and adults get prednisone?


Please give specific answers to each and any citations would be greatly appreciated!

Searched internet for term "nsaid induced asthma" brought many results.
Note: NSAID means: naproxen, aspirin, ibuprofen....

SOURCE: http://www.ncbi.nlm.nih.gov/pubmed/16579869
Mechanisms of aspirin sensitivity.
Picado C1.
Author information

Abstract
In some asthma patients, nonsteroidal anti-inflammatory drugs (NSAIDs) induce bronchospasm, rhinorrhea, and nasal obstruction.

NSAID-induced reactions appear to be caused by the inhibition of cyclooxygenase-1 (Cox-1); this in turn activates the lipoxygenase pathway, which eventually increases the release of cysteinyl leukotrienes (Cys-LTs) that induces bronchospasm and nasal obstruction. With regard to the metabolism of arachidonic acid (AA) in NSAID-intolerant asthmatic patients, the following changes have been observed: 1) A low production of prostaglandin E2, seemingly due to deficient Cox-2 regulation; 2) an increased expression of leukotriene-C4 synthase; and 3) a reduced production of metabolites (lipoxins) released through the transcellular metabolism of AA. NSAID-intolerant asthmatics have higher basal levels of Cys-LT than NSAID-tolerant asthmatics. Moreover, Cys-LT levels in NSAID-intolerant asthmatics increase remarkably following NSAID provocation testing. There has been no explanation to date that connects all these findings, although an anomaly in the regulation of Cox-2 is probably accountable.

SOURCE: http://www.ncbi.nlm.nih.gov/pubmed/16579869

 

[BidingMyTime]

Prednisone liquid is the nastiest tasting stuff. In my hospital, if a doctor does order prednisone liquid for anyone, its autosubbed with tablets & the nurses crush the tablets.

 

[student12399]

Please note: infant UNDER 1 YEAR can get prednisone liquid.
But, because of bad taste, prednisone liquid is not preferred.
prednisolone liquid by brand name ORAPRED is ORALLY PREFERED (manufacturer made the name easy to remember)

Source: to prove that under 1 year old can take prednisone.
http://www.drugs.com/dosage/prednisone.html
Usual Pediatric Dose for Asthma
< I year:
acute: 10 mg orally every 12 hours.
maintenance: 10 mg orally very other day.

1 to 4 years:
acute: 20 mg orally every 12 hours.
maintenance: 20 mg orally every other day.

5 to 12 years:
acute: 30 mg orally every 12 hours.
maintenance: 30 mg orally every other day.

>12 years:
acute: 40 mg orally every 12 hours.
maintenance: 40 mg orally every other day.

http://www.drugs.com/dosage/prednisone.html

Current product:
Prednisone Oral solution
Prednisone 5mg/5ml Solution (00054-3722) (Roxane Laboratories Inc)

Prednisone 5mg/5ml Solution (00054-8722) (Roxane Laboratories Inc)

Prednisone Intensol 5mg/ml Solution (00054-3721) (Roxane Laboratories Inc)

**************
Now, the answer to your question:


Liquid often have bad taste. Orapred is prednisolone liquid that is less nasty and has less chance of vomiting.

Therefore, good guess is: doctors often give liquid prednisolone ORAPRED to children to reduce the chance of vomiting.

Source: http://www.ncbi.nlm.nih.gov/pubmed/16801838

Oral corticosteroids are an essential part of the management of children with acute asthma exacerbations. Vomiting is a frequently cited problem attributed to oral corticosteroids. A new formulation of prednisolone, Orapred, claims to have improved palatability that may decrease the incidence of vomiting.

CONCLUSIONS:
In our study population, Orapred was associated with a significant less incidence of vomiting and better taste score compared to the generic prednisolone.
Source: http://www.ncbi.nlm.nih.gov/pubmed/16801838

Wow you are definitely a helpful pharmer! Thanks SO much for the info and citations! And thanks to all those who contributed info as well.

 

[npage148]

Might as well toot my own horn with this reference. Good review of mechanism of Asa induced astnma

http://www.ncbi.nlm.nih.gov/m/pubmed/17200429/