are you sure youre not mistaking hydrogen peroxide for the more abrasive rubbing alcohol???
Here's a scientific study on hydrogen peroxide and how it acts in wounds.
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WEBSITE:
http://heartlung.osu.edu/article.cfm?ID=2229
COLUMBUS, Ohio Ohio State University medical researchers have demonstrated that reactive oxygen species at appropriate levels can support the healing of wounds, and specifically that wounds can generate their own low concentration of hydrogen peroxide, which has a role in healing.
A recent Ohio State study showed that at the site of injury, cells of wound tissue convert oxygen to reactive oxygen species, triggering oxidation-reduction, or redox driven mechanisms. Excess levels of reactive oxygen species, such as during chronic inflammation, may impair healing, but low levels offer healing benefits.
The observation that the redox state of the wound tissue may influence healing outcomes could lead to consideration of a novel redox-based principle for wound therapy, said Chandan Sen, lead author of a paper detailing the findings and professor and vice chair of the department of surgery at Ohio State.
The research paper is available in the online version of Molecular Therapy, the journal of the American Society of Gene Therapy.
A key characteristic of problem wounds is that they are hypoxic, or suffer from poor oxygenation, meaning too little oxygen is available to initiate the reactive oxygen-dependent healing processes.
Proper oxygenation of a wound is a fundamental pre-requisite, said Sen, also deputy director of the Davis Heart and Lung Research Institute at Ohio State and chief editor of the international journal Antioxidants and Redox Signaling.
Under conditions of sufficient oxygenation, wound-related cells generate small amounts of reactive oxygen products, including hydrogen peroxide, which, at correct levels, acts as a chemical messenger to support healing. The hydrogen peroxide in question is not the typical household strength 3 percent solution, but a lower concentration of the compound that at a molecular level sends a message needed to trigger angiogenesis, or the formation of new blood vessels, the scientists found.
Their study provides the first direct evidence that low levels of hydrogen peroxide are enzymatically generated by the body as a wound heals in healthy tissue.
Problem wounds, however, may suffer from conditions that limit hydrogen peroxide production at the wound site. These conditions cause improper oxygenation and compromised immune function, or stem from genetic defects or chronic conditions such as diabetes that compromise the enzyme NADPH oxidase, a cellular mechanism behind the ability to kill bacteria. In these and similar cases in which the body cant be counted on to heal itself, appropriate delivery of reactive oxygen species could provide a new basis for therapeutic exploration, the scientists said.
Were saying that the body makes hydrogen peroxide at very minute dosages that act as a signal for repair, Sen said. An excess of hydrogen peroxide can be damaging, but if we can find an innovative approach to deliver low levels of hydrogen peroxide into wounds that are difficult to heal, that could be helpful.
Basic science studies have identified hydrogen peroxide as a trigger that drives redox signaling. Redox-based strategies to heal problem wounds may be applicable to a large number of people suffering from chronic wounds, such as diabetics, the immune-challenged and those suffering from chronic granulomatous disease, he added.
To mirror those conditions, Sen and colleagues designed a study to compare wounds in mice with compromised health specifically, mice deficient in MCP-1, a protein known for its involvement in recruitment of immune cells to wounds and in the formation of blood vessels, and others deficient in p47phox, a member of NADPH oxidase family to wounds in mice with normal health to monitor molecular activity under varying conditions. In mice with built-in deficiencies whose wounds were not healing, the topical application of low-dose hydrogen peroxide identical to the concentration that occurred naturally in healthy mice corrected abnormal wound closures, the study reports.
Scientists determined that one key role of hydrogen peroxide in wound healing is to induce vascular endothelial growth factor in wound-related cells, a gene believed to be the most efficient signal to stimulate blood vessel formation in wounds.
Using a viral gene delivery approach involving catalase, an enzyme that rapidly decomposes hydrogen peroxide, scientists also showed that forced decomposition of hydrogen peroxide generated by the wound tissue results in impaired healing. Sen said these observations underscore the significance of hydrogen peroxide, generated by wound cells, in deciding healing outcomes.
Sen said the study sets a new paradigm supporting the role of reactive oxygen species generated from oxygen as a signal for repair in the healing process. He added that these new findings also underscore the critical need to ensure that wounds are appropriately oxygenated.
A strong solution of hydrogen peroxide has been historically used clinically to disinfect wounds. While such an approach may be effective in disinfecting, hydrogen peroxide at that strength may hurt newborn regenerating tissue. The study showed that too much hydrogen peroxide can be damaging to a wound.
Our observation that dermal wound healing is subject to redox control represents an important step toward redox-based therapies in the clinic, Sen said. The solution to problem wounds lies in an interdisciplinary multifactorial approach. To enable that solution, all facets of a problem wound need to be mechanistically understood. The redox control aspect represents a new facet.
A grant from the National Institute of General Medical Sciences of the National Institutes of Health supported this work.
Sen co-authored the study with Sashwati Roy, Savita Khanna and Koshore Nallu, all with the OSU Laboratory of Molecular Medicine, and Thomas K. Hunt of the University of California at San Francisco Department of Surgery.
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DOROTHY M. DAVIS
HEART AND LUNG
RESEARCH INSTITUTE
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with this new information, would the hydrogen peroxide treatment be acceptable?