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We've been getting a few cases of perineural invasion from skin cancers over the past few months. I had a question about one such guy I recently saw
71 yo man with a distant history of resected skin cancers now presented with 3 months of worsening facial numbness in maxillary trigeminal distribution (V2). MRI showed V2 nerve enhancement extending from Meckel's cave to foramen rotundum concerning for perinerual invasion. No visual sxs. Had a right cheek melanoma 8 years ago completely resected no PNI, no adjuvant tx recommended and a left neck melanoma with negative neck dissection 10 years ago. Otherwise no significant skin history, not a guy with much in the way of sun spots/skin irregularities. ENT attempted biopsy of right infraorbital nerve and a benign looking lesion on the right cheek all negative.
Just curious if people have thoughts. What further wkup would you do (anything that can mimic this type of situation)? What RT dose/fractionation would you consider, what to cover and constraints to consider. Concurrent chemo? Appreciate the thoughts
71 yo man with a distant history of resected skin cancers now presented with 3 months of worsening facial numbness in maxillary trigeminal distribution (V2). MRI showed V2 nerve enhancement extending from Meckel's cave to foramen rotundum concerning for perinerual invasion. No visual sxs. Had a right cheek melanoma 8 years ago completely resected no PNI, no adjuvant tx recommended and a left neck melanoma with negative neck dissection 10 years ago. Otherwise no significant skin history, not a guy with much in the way of sun spots/skin irregularities. ENT attempted biopsy of right infraorbital nerve and a benign looking lesion on the right cheek all negative.
Just curious if people have thoughts. What further wkup would you do (anything that can mimic this type of situation)? What RT dose/fractionation would you consider, what to cover and constraints to consider. Concurrent chemo? Appreciate the thoughts