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Daddy Robbins (new) pg. 118-119 says "The binding of coagulation factors II, XII, IX, and X to calcium depends on the addition of gamma carboxyl groups to certain glutamic acid residues on these proteins. This reaction uses Vitamin K as a cofactor and is antagonized by drugs such as coumadin.."
My notes from class and Goljan (new) say its factors II, VII, IX and X that undergo Vit K dependent gamma carboxylation (which I assumed then allows them to bind calcium). So the odd one out in Robbins is factor XII. Can anyone elaborate on this? Thanks in advance.
My notes from class and Goljan (new) say its factors II, VII, IX and X that undergo Vit K dependent gamma carboxylation (which I assumed then allows them to bind calcium). So the odd one out in Robbins is factor XII. Can anyone elaborate on this? Thanks in advance.