If you dont understand normal physiology you wont understand the abnormal - at least not completely. Step I has 2-step reasoning questions, meaning basically that you have to have some depth to your knowledge of a topic. Sadly lots of M1 and M2 professors write garbage exams that encourage memorization of factoids and superficial level understanding in order to do well on the class exams... But i digress
A good usmle question will be like: "patient 26 y/o female comes to your office with disorder of conjugate lateral gaze etc etc (describing INO),
Then the stem will NOT be "what is the most likely diagnosis?" (1 step reasoning - all you have to know is INO in young people is most often MS - you couldve memorized that from 1 powerpoint slide and knew jack about MS. The Step I stem will instead be like, "what is the most likely cause of this patients motor deficits?" Then the answer would be something like "impaired saltatory conduction" or something of that nature with a few red herring answers. Basically you would have to know first that MS causes demyelination and second what the significance of that is (what myelination provides normal axons) and third what specifically of all the changes caused by the disease result in the specific problem exhibited in the question.
So anyway the reason i use this example is because to answer these types of questions you really have to know about normal -> process of becoming abnormal -> reason why things stay abnormal.
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