I can't seem to find the dose constraints for the Turrisi regimen for bid treatment of SCLC. Anyone have them by any chance?
I would refer to the current RTOG 0538/CALGB 30610 which has that as a trial arm. I usually get these through the RTOG website but since its a joint trial, its not readily available. Here is a .pdf of a version of the trial that I found via Google.
http://www.kccop.org/pdfs/FullProtocol-2521153731.pdf
My biggest problem with the Turrisi regimen is what to give to the supraclavicular area. The original trial excluded N3-disease, but I'd like to use the regiment for N3 too.
What am I allowed to give to the plexus?
In the current CALGB trial supraclavicular nodes are permitted, and no brachial plexus tolerance is set.
How often does it happen with H&N?Yes, in 70 Gy arm they will surely see some brachial plexus events.
I've seen data all over the place.More often than widely recognized, actually.
Yeah I remember that now, although the difference is that the high-dose arm was going to 74 rather than 70 Gy. I think the controversy I see is whether the BP can tolerate 66 or 70 GyRTOG 0617 had to amended half way through to exclude apical tumors.
Thanks for those references, MG, those are useful.
It looks like even with 66-70 Gy, the incidence remains quite low.
Seper - why do you say underreported? Are you seeing it? I never have seen it. I hadn't been contouring it initially, because what I had read in the past indicated that prior to realizing it needed to be contoured, people were blasting it to 66-70 Gy and less than 5% risk of it. With the risk being so low, it would be quite low on the priorities for an IMRT plan.