I am sorry, but I can't make sense of your post.
I can tell you for sure that what you said in the middle is half correct, but you are missing the main idea of this entire concept.
Here's what I know for sure:
Mitochondrial uncouplers, such as UCP, 2-4DNP, asprin, thermogenin disrupt the proton gradient across the innner mitochondrial membrane. Without a proton gradient, there is nothing driving ATPsynthase and thus no ATP being produced.
What happens inside the cell when ATP gets low.............. the cell will try to make more ATP. How does a cell make more ATP...................it increases electron transport. This is where the cell runs into trouble.
It is shunting all of its energy down the electron transport chain, and using up all of its oxygen (because oxygen is the terminal electron acceptor).
Thus, increasing oxygen consumption But the poor cell is fighting an uphill battle. All of the protons that are being pumped to the mitochondrial intermembrane space are sneaking back into the matrix because of the uncoupling agent. Thus, no ATP is being produced.
Bottom line: The uncoupler decreases the proton gradient, decreases ATP synthesis, but
INCREASES oxygen consumption becuase it is still trying to make ATP, it just can't. So ATP synthesis stops, but oxygen utilization continues as the cell tries to make up for it's decreased ATP.
Now think about the hyperthermia effect, the whole reason you get hyperthermia is the cell is constantly producing excess heat from the excess electron flow. The only way electrons can flow is if oxygen is waiting at the end ready to take them away. So you can't get hyperthermia if oxygen consumption stops.
I hope that helps, and sorry in advance for typos.
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P/O ratio - ATP molecules produced per O atom reduced.
NADH - P/O ratio of 3
FADH - p/O ratio of 2
2,4-dinitrophenol, an uncoupler that dissipates the H+ gradient has a P/O ratio of 0. [info from kaplan, pg. 34]
Having said that, Uncoupling agents 2,4-DNP, aspirin, Thermogenin [protein in brown fat], UCP, CCCP, FCCP would cause:
Increase permeability of membrane
Decrease proton gradient
Decrease O2 consumption
CCCP --> carbonyl cyanide m-chloro phenyl hydrazone.This is a lipid-soluble weak acid which is a very powerful mitochondrial uncoupling agent.
FCCP --> p-trifluoromethoxy carbonyl cyanide phenyl hydrazone (similar to above)
UCP --> from FA, dont know this one. neone?