Excess GAGs(Glycosaminoglycans)

[Miracoli]

Please can you name 3 conditions in which you will see Excess extracellular Glycosaminoglycans(GAG)? What do we call them clinically?

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[Transposony]

Mucopolysaccharidosis are part of the lysosomal storage diseases due to disorder of lysosomal enzymes needed to break down molecules called glycosaminoglycans.
e.g. Hunter, Hurler Syndromes b(FA 2014 Page 114) & Sanfilippo syndrome.

 

[Miracoli]

Mucopolysaccharidosis are part of the lysosomal storage diseases due to disorder of lysosomal enzymes needed to break down molecules called glycosaminoglycans.
e.g. Hunter, Hurler Syndromes b(FA 2014 Page 114) & Sanfilippo syndrome.[/QUOTEI
Sorry, I should have added extracellular. Thanks

 

[Transposony]

Sorry, I should have added extracellular. Thanks

GAGs are located primarily on the surface of cells or in the extracellular matrix (ECM).
http://en.wikipedia.org/wiki/Extracellular_matrix
Components of the ECM are produced intracellularly by resident cells and secreted into the ECM via exocytosis.
http://themedicalbiochemistrypage.org/glycans.php

 

[Miracoli]

GAGs are located primarily on the surface of cells or in the extracellular matrix (ECM).
http://en.wikipedia.org/wiki/Extracellular_matrix
Components of the ECM are produced intracellularly by resident cells and secreted into the ECM via exocytosis.
http://themedicalbiochemistrypage.org/glycans.php

Right. I was talking about myexedema and myxomatous degeneration.
Etiology for myxomatous degeneration? Tissue/structure where it occurs?