I just started medical school so i haven't tried this, but I do have a friend who is a second year that does this at a MD school and does very will with it.
Most people (including myself) at my school annotate first aid with additional notes during that respective block. It's a good way to actively study and give yourself a great resource once boards come around
Before each block - NO.....If you can read, understand and retain that information before any class or guidance, more power to you. Sure you may pick up a thing here or there, but no need for it.
during each block - YES, w/ annotations. It'll help make sure your school is doing there job, and help you prepare for boards without going to crazy
I personally read it the first day or 2 at the beginning of the block to get a general overview. Generally there is a lot of good info, but it has a ton of stuff your lecturers won't test you on.
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