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Did you read the paper? They randomized people by their trial design to ensure 8 to 2.5 to 1 so the "outcome" of the ratio was not relevant. Then they compared a SINGLE FIT to CTC. FIT has never worked as a single test and they know it will perform poorly. There was no statistical difference between colonoscopy and CTC despite higher detection rates with colonoscopy because they only did 150 colonoscopies (a screening study with 150 colos? thats just lazy). Advanced neoplasia is detected in as more like 10-12% of colonoscopies in the larger better studies. Other than the initial papers, I've yet to see a CTC paper that wasn't designed to get the desired outcome. You can almost hear the evil laughter as they figure out the desired outcome and work backwards. Once again, find me the paper that shows that CTC prevents cancer death. Otherwise you should post your crap research in the radiology forum.