gluconeogenesis and fatty acid oxidation

[theonlytycrane]

(From KA) - They must mean that fatty acid oxidation fuels gluconeogenesis in terms of generating some ATP to drive gluconeogenesis? Because acetyl-coa from f.a. oxidation can't be converted back into glucose.

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[aldol16]

(From KA) - They must mean that fatty acid oxidation fuels gluconeogenesis in terms of generating some ATP to drive gluconeogenesis? Because acetyl-coa from f.a. oxidation can't be converted back into glucose.

Yes, they mean that the fuels generated from beta oxidation (aka acetyl-CoA) can then enter the TCA cycle and yield huge amounts of energy, which then drives the energetically unfavorable gluconeogenesis (remembers that gluconeogenesis consumes 2 net ATP).

 

[theonlytycrane]

Are you counting from oxaloacetate -> PEP (1) and 3PG -> 1,3-BPG (2)?

 

[aldol16]

Are you counting from oxaloacetate -> PEP (1) and 3PG -> 1,3-BPG (2)?

Sorry, I meant 6 ATP equivalents for gluconeogenesis. 2 from pyruvate to OAA, 2 from OAA to PEP, and 2 from 3-phosphoglycerate to 1,3-BPG. If you traverse the entire cycle from glycolysis back to glucose via gluconeogenesis, that's 4 lost.