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So lately our hospital has been seeing an epidemic form of a uncomfortable but benign condition that has mutated into something much more difficult to treat. Even more scary, it doesn't seem to be respecting traditional risk factors and vulnerable populations. It gets worse in that one of our front-line drugs for this condition is no longer available due to manufacturing issues. Please let me know if you've seen this disease entity and if you've found an effective treatment.
I don't know if it's already been described in the specialist literature, but I call this disease - Multi-Drug Resistant Abdominal Pain (MDRAP). While it's been previously seen in populations with diabetic gastroparesis, cyclic vomiting, fibromyalgia, and narcotic dependence lately we've had a run (3-4/shift) of previously healthy patients who have benign histories, typically LUQ ttp, and completely negative work-ups (including CT w/IV&PO contrast on those who required admission). Neither protonix, GI cocktails, hyocyosamine, or multiple high doses of IV narcotics (typical dose range 12-24mg morphine equivalent) provides pain relief and these patients are typically admitted for symptom control with a negative in-patient GI work-up.
I don't know if it's already been described in the specialist literature, but I call this disease - Multi-Drug Resistant Abdominal Pain (MDRAP). While it's been previously seen in populations with diabetic gastroparesis, cyclic vomiting, fibromyalgia, and narcotic dependence lately we've had a run (3-4/shift) of previously healthy patients who have benign histories, typically LUQ ttp, and completely negative work-ups (including CT w/IV&PO contrast on those who required admission). Neither protonix, GI cocktails, hyocyosamine, or multiple high doses of IV narcotics (typical dose range 12-24mg morphine equivalent) provides pain relief and these patients are typically admitted for symptom control with a negative in-patient GI work-up.