Do something you really enjoy, but also something you will excel in. Also, be aware that you may not get in right after 4 years, so put yourself in a position to have a productive gap year (or few) if need-be, whether that means networking, having internships, taking classes that will give you skills marketable in the private sector or whatever.
I got stuck in a rut of doing things I thought would look good for apps/jobs: taking unnecessary and hard upper division classes, picking up minors, etc. I got stuck in the circlejerk mentality of my science major and I hoped to get things that would make me look good on paper. I would've been happier giving up a few of those hard science classes to learn another language while I was still in college, study abroad or spend time tutoring kids in my community, all things I gave up for research and science courses that in all reality I won't directly apply in my life after college.
You can check boxes and be miserable or you can plan ahead, follow your passions and still have all the dorky pre-med pre-reqs completed.