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Can anyone explain how renal tubular acidosis type 2 leads to hypokalemia?
From what I've read up so far, it seems like there are two opposing forces happening that affect potassium levels in the serum vs. urine. The defect in HCO3- reabsorption at PCT results in metabolic acidosis, which leads to hyperaldosteronism because patients tend to get dehydrated, and hypderaldosteronism results in hypokalemia.
But doesn't RTA type 2 also lead to urine acidification by alpha-intercalated cells as an attempt to distally correct the metabolic acidosis, which would lead to hyperkalemia? Is there something else I'm not factoring in here?
From what I've read up so far, it seems like there are two opposing forces happening that affect potassium levels in the serum vs. urine. The defect in HCO3- reabsorption at PCT results in metabolic acidosis, which leads to hyperaldosteronism because patients tend to get dehydrated, and hypderaldosteronism results in hypokalemia.
But doesn't RTA type 2 also lead to urine acidification by alpha-intercalated cells as an attempt to distally correct the metabolic acidosis, which would lead to hyperkalemia? Is there something else I'm not factoring in here?