Is a lipid anchored protein an integral or peripheral protein?

[panmit]

Is a lipid anchored protein an integral or peripheral protein?

I think it is a integral protein because it is covalently linked inside the membrane. What do you guys think?

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[DogeDDS]

Edit. Nevermind

 

[Daneosaurus]

It's neither. They are their own class: lipid-anchored proteins. Integral proteins extend through both of the bilayers, peripheral proteins attach on either side of the bilayer, lipid-anchored covalently attach to either the N-terminus of the internal lipid structure or to the cysteine residues.

 

[panmit]

transmembrane proteins extend through both bilayers. Its a type of integral protein. Integral proteins do not necessarily have to extend through both layers

 

[BrazilianRider]

Panmit is right. I took a Eukaryotic Cell Structure course over the past semester and everything except Protein-Bound Proteins are basically Integral Proteins.

If it's a protein bound to an Integral Membrane Protein, then it is Peripheral.

Remember that you only need salts or a pH change to isolate Peripherals, but you need detergent to isolate Integrals.