KA ACE inhibitors passage

[basophilic]

Question 2
Based on this passage, which of the treatment groups from the initial experiment would the results of the new treatment group with “Drug X” most likely resemble and why?
Please choose from one of the following options.
A. The Captopril group, because the actions of Drug X and Captopril both result in a net decrease in renin
B. The Eprosartan group, because neither Drug X nor Eprosartan would inhibit the degradation of bradykinin
C. The Eprosartan group, because the inhibition of renin would mimic the blood pressure effect of blocking AT receptors
D. The Captopril group, because the actions of Drug X and Captopril both occur higher in the RAAS pathway than Eprosartan
Anyone who has done this passage? Why is C incorrect: if you block renin and angiotensin, then both effectively lower blood pressure. For choice B: Drug X inhibits renin, so doesn't it indirectly inhibit bradykinin degradation? B is the correct answer.
Let me know if you need more info.

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[Ossyaris]

bump
link for the passage the question is referring to:
https://www.khanacademy.org/test-pr...s-and-the-renal-regulation-of-blood-pressure-

 

[bee17]

B is the best choice. ACE is what degrades bradykinin, and the inhibition of renin does not affect ACE.

 

[OrdinaryDO]

The way I would interpret this passage is that Drug X works as a direct renin inhibitor (" The mechanism by which this is achieved is through the direct inhibition of renin." from KA.) This would be identical to an ARB due to its function of blocking receptor sites on angiotensin ("angiotensin receptor blockers (ARBs)") which would follow toward producing the same effects on the system.