SDN Members don't see this ad. (About Ads) I am considering using low dose Ketamine in conjunction with Versed for sedation. It seems to me to be a great combination from a safety standpoint, especially when considering lack of respiratory depression. Also, it is unlikely the chronic pain patient would be tolerant to Ketamine as they are with Fent and Benzos like Versed. What are your thoughts? BTW, I am not an anesthesiologist.