Thanks for the input, everyone.
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The neo dose here is very high while Norepi is too low, I think the neo is not doing anything anymore due to tachyphylaxis and it can be stopped.I wouldn't do it either. If norepi is maxed out and your patient is still hypotensive, I would be worried that the patient either doe not have enough volume or not enough contractility. An echocardiogram would be indicated in that case to differentiate the two. Adding on more alpha at that point can make the situation worse IMHO.
Although 4 mcg/min norepi is only .06 mcg/kg/min in this patient so you have room to go up on it so I would do that first, assuming this is early stage sepsis.
Makes no sense. Some ICUs can be very scary.
I got a call one time from a radiologist who needed emergent nephrostomy tubes in a patient. The patient was "actively decompensating" and "maxed out on levophed" in the ICU.
"You need to get here ASAP!"
What was the line and intubation status, you ask?
The levophed was going through a PIV, no arterial line, and the patient was on a Venti mask.
Levo is 4mcg/min, neo is 50mcg/min. Pt is 60kg, about 6foot or 6foot-1.
If norepi is maxed out
Not very elegant but I'm sure it works just fine.Septic pt in the ICU at OSH on Levophed and Neosynephrine. We would never do that at my institution. Thoughts?
Levo is 4mcg/min, neo is 50mcg/min. Pt is 60kg, about 6foot or 6foot-1.
Maxed out typically for me is 0.3 mcg/kg/min. Although I know that it can continue to be effective at higher doses, I would want to rethink the situation as to whether the patient needs more alpha versus volume verdus beta.What is your definition of maxed out?
Ive seen dobutamine work in sepsis but am not sure why. Is it just the better cardiac output? Doesn't it decrease PVR? Exactly what we don't want?
...why is a "septic" patient on Neosynephrine?
Usually if you need inotropy (because your patient is circling the drain on NE/vaso) you don't have any BP to work with, which makes dobutamine a poor choice.
My progression is fluid+NE --> NE+vaso --> NE+vaso+epi with more fluid given along the way based on PPV or TTE. Give these additions 60-120 minutes to have an effect and reassess.
Agree that norepi max effect is probably somewhere around 0.2-0.3mcg/kg/min
One place I trained, the default norepi order came with a RN titration dose range "1mcg/min to 80mcg/min," particularly memorable to see the patient with acute MR not doing so well, to find out that hey guess what the patient's on 80mcg/min norepi!