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Hypocalcemia causes a decrease in threshold potential, explaining why you get all those hyperexcitability signs with a low serum Ca2+. Hypercalcemia does the opposite.
My understanding was that the threshold potential is the point where Na+ conductance (and influx) just exceed K+ conductance (and efflux). Based on this, these serum calcium levels must be having some sort of effect on the sodium or potassium channels.
I looked through a bunch of texts and online and couldn't find any explanation as for how changes in serum calcium alter the threshold potential. Is this just because nobody has any idea?
My understanding was that the threshold potential is the point where Na+ conductance (and influx) just exceed K+ conductance (and efflux). Based on this, these serum calcium levels must be having some sort of effect on the sodium or potassium channels.
I looked through a bunch of texts and online and couldn't find any explanation as for how changes in serum calcium alter the threshold potential. Is this just because nobody has any idea?