Hi everyone, I was curious to know how my pathology colleagues viewed the potential of raman spectroscopy as an ancillary tool for cancer diagnostic and whether it could replace morphology one day.
My personal opinion is that we are still decades away of it making into ex vivo diagnosis given the fact that most studies are based on a subset of neoplasms with specific morphological features (such as small round blue cell tumors) and thus simplifying the pathological assessment by alot.
Furthermore, the best that raman spectroscopy can hope to achieve at this point is to prove non-inferiority compared to the gold standard pathological assessment. Kind of like how digital pathology has achieved when compared to standard microscopic assessment.
Some people are however using it for intraoperative tissue assessment as seen in this recent paper: http://stm.sciencemag.org/content/7/274/274ra19.
Curious to see what you guys are thinking, cheers!
My personal opinion is that we are still decades away of it making into ex vivo diagnosis given the fact that most studies are based on a subset of neoplasms with specific morphological features (such as small round blue cell tumors) and thus simplifying the pathological assessment by alot.
Furthermore, the best that raman spectroscopy can hope to achieve at this point is to prove non-inferiority compared to the gold standard pathological assessment. Kind of like how digital pathology has achieved when compared to standard microscopic assessment.
Some people are however using it for intraoperative tissue assessment as seen in this recent paper: http://stm.sciencemag.org/content/7/274/274ra19.
Curious to see what you guys are thinking, cheers!
