This is a very popular question and I'm probably going to give a very long answer.
We typically like to see out-of-state applicants with science GPAs and MCATs that are close to our averages of 3.6 and 27 (keep in mind we take the highest sub-score from multiple test dates to make a new total, combined score).
However, having said that, we actually do read each file that becomes complete (meaning that all required paperwork has been submitted), so we are very interested in what each student, out-of-state or in-state can bring to the class. Students slightly below the numbers mentioned above can still have a very good chance based on upward grade trends, letters of recommendation, clinical/shadowing experience, research experience, community service, and desire to be an osteopathic physician (your essays are extremely important!).
Sort of related to this question... we see tons people anxious to know "what they need to get in" or what "they need to do to get an interview". We know folks are looking for a quantitative answer, but the truth is it is very difficult to give one. There are many, many in and out-of-state people who apply with grades and MCATs far above our averages but they may never get an interview, or if they do get an interview, they may not be a good match for our program and therefore our selection committee may choose not to accept them.
The best advice I can give to potential applicants is, apply when you feel you have done all you can to be the best applicant possible and then let the process run its course. Also, remember that there is no law that says one has to enter medical school immediately upon graduation. Everyone takes a different path and that is completely okay.
Apologies for the mini-dissertation on applications-I guess I'm feeling very philosophical this morning.
Please keep your questions coming and I will do my best to answer them (maybe even under 5,000 words next time!).