- Joined
- Jul 12, 2007
- Messages
- 723
- Reaction score
- 22
In Parkinson's, my understanding is that the indirect pathway (inhibitory or slow movements) is in overdrive...aka:
Stn stimulating Gpi which inhibits the thalamus
In terms of surgical options, correct me if I am wring, but it seems to make sense for you to either knock out Stn or Gpi to let the thalamus stimulate movement.
Hence, stereotactic surgery aka pallidotomy or stn-removal would work.
For DBS, when I read online, why are the targets GPi and Stn and NOT the thalamus...aka why are you further "stimulating" the inhibitory component ....or am I mistaken and instead, does DBS "inhibit" the GPU and STn?
Thanks.
Stn stimulating Gpi which inhibits the thalamus
In terms of surgical options, correct me if I am wring, but it seems to make sense for you to either knock out Stn or Gpi to let the thalamus stimulate movement.
Hence, stereotactic surgery aka pallidotomy or stn-removal would work.
For DBS, when I read online, why are the targets GPi and Stn and NOT the thalamus...aka why are you further "stimulating" the inhibitory component ....or am I mistaken and instead, does DBS "inhibit" the GPU and STn?
Thanks.