Qn about Abdominal aortic aneurysm

[ashik33]

Why are most abdominal aortic aneurysms located below the level of renal arteries?

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[Phloston]

The aorta itself is supplied by small blood vessels called the vasa vasorum.

You've gotta know that the vasa vasorum ends at the level of the renal arteries.

This means the abdominal aorta below L2 is dependent on luminal O2 diffusion for adequate oxygenation.

In turn, this means the aorta is thinner below L2, thereby predisposing to aneurysm.

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Now that I answered yours, maybe you'll respond to my thread on interferon?

 

[chaotic mind]

Why are most abdominal aortic aneurysms located below the level of renal arteries?

The most common cause of abdominal aortic aneurysm is atherosclerosis.Atherosclerosis preferentially affects the abdominal aorta.

 

[Phloston]

The most common cause of abdominal aortic aneurysm is atherosclerosis.Atherosclerosis preferentially affects the abdominal aorta.

Endothelial cell injury is the first step in that process. Without vasa vasorum, the rate of vessel repair is lesser.

 

[ashik33]

The aorta itself is supplied by small blood vessels called the vasa vasorum.

You've gotta know that the vasa vasorum ends at the level of the renal arteries.

This means the abdominal aorta below L2 is dependent on luminal O2 diffusion for adequate oxygenation.

In turn, this means the aorta is thinner below L2, thereby predisposing to aneurysm.

----

Now that I answered yours, maybe you'll respond to my thread on interferon?

Thanks. I wished I could answer your question. I just reviewed Jawetz and surprisingly, they too were confused To be true, I am pretty weak when it comes to immunology (and i am too lazy to review multiple sources as well...)

 

[chaotic mind]

Endothelial cell injury is the first step in that process. Without vasa vasorum, the rate of vessel repair is lesser.

is the concept of no vasa vasorum below the renal arteries from goljan lectures?

 

[Phloston]

is the concept of no vasa vasorum below the renal arteries from goljan lectures?

I only listened to about half of the lectures so I'm not really sure. I don't even know where I had learned/heard that from.

 

[rollelephants]

according to Robbins, the medial weakening in AAA is due to increased diffusion distance to the INNER part of the media due to atherosclerosis (versus a thoracic aortic aneurysm, which the outer part of the media is ischemic from the vaso vasorum being narrowed by hypertension)

since that part of the aorta is the most common place for atherosclerosis, that's why there is the medial weakening and aneurysm there

 

[Suncrusher]

I only listened to about half of the lectures so I'm not really sure. I don't even know where I had learned/heard that from.

It's in pathoma, GT, and other resources

 

[fleshwound]

is the concept of no vasa vasorum below the renal arteries from goljan lectures?

yes, goljan mentions it

 

[chaotic mind]

according to Robbins, the medial weakening in AAA is due to increased diffusion distance to the INNER part of the media due to atherosclerosis (versus a thoracic aortic aneurysm, which the outer part of the media is ischemic from the vaso vasorum being narrowed by hypertension)

since that part of the aorta is the most common place for atherosclerosis, that's why there is the medial weakening and aneurysm there

thats what I remember from robbins.
also,
1)the aorta below the renal vessels has lesser vasa vasorum than the thoracic(v/s no vasa vasorum)
2) it is also subject to greater stress during systole and diastole.
3) its wall is slightly thinner in the abdomen
4)role of metalloproteinases,inflammation=implicated in familial clustering.
so its a combination of these factors which make it more prone to aneurysms.
I havent come across any source which stated it was due to absense of vasa vasorum as the initiator/most important factor.

haven't come across it in GT either.

 

[Suncrusher]

haven't come across it in GT either.

 

[chaotic mind]

thanks for the input.