Hello I have a question about the Schilling's test + Pernicious anemia.
1. In 80-95% of pernicious anemia, I can see how giving radioactive IF would help in Pernicious Anemia in the case where , antibodies are attacking the parietal cells, thereby no IF (production and) is extruded into the fundus/body of the stomach to attach to B12. . ....... [ok no production of IF, give radioactive IF as per Schilling's test]
2. In 60-75% of cases of pernicious anemia, the antibodies involved in the type II hypersensitivity reaction block the binding of B12 to IF to make the cobalamin-IF complex. -----> Where the IF is being blocked from binding b12/cobalamine how does the Schilling's test account for that as radioactive B12 cannot help that.
3. In 30-50% of cases, the antibodies attack the terminal Ileum receptor (possibly cubulin receptors???) by blocking the attachment B12-IF to said receptors---> Again radioactive B12 will not solve this issue.
I hope this confusion does bite in ass during the stupid Step 1.
1. In 80-95% of pernicious anemia, I can see how giving radioactive IF would help in Pernicious Anemia in the case where , antibodies are attacking the parietal cells, thereby no IF (production and) is extruded into the fundus/body of the stomach to attach to B12. . ....... [ok no production of IF, give radioactive IF as per Schilling's test]
2. In 60-75% of cases of pernicious anemia, the antibodies involved in the type II hypersensitivity reaction block the binding of B12 to IF to make the cobalamin-IF complex. -----> Where the IF is being blocked from binding b12/cobalamine how does the Schilling's test account for that as radioactive B12 cannot help that.
3. In 30-50% of cases, the antibodies attack the terminal Ileum receptor (possibly cubulin receptors???) by blocking the attachment B12-IF to said receptors---> Again radioactive B12 will not solve this issue.
I hope this confusion does bite in ass during the stupid Step 1.