A member asks: I will leave it to others to provide specific advice about pharm as it's been a long long time since I studied that. I would say that although doing well in the pre-clinical time period is helpful, it will not be likely to make or break your residency application except "maybe" for some of the most competitive specialties. Regardless, your USMLE scores can help here. Beyond this advice though, and specific studying advice others can give, I'd like you to try to think about regaining some of the energy that brought you into medical school. That is, don't be convinced that your worth as a doctor is related to your grades or step scores, but in what you can contribute to the care of your patients and how you can enjoy the practice of medicine. This will ultimately determine your long-term career satisfaction. So, if you are inclined, talk to some faculty that you admire or otherwise wish to emulate about their careers and focus on the positives. That is, you are "in" a medical school, you are moving towards the clinical years, and you have the opportunity to practice medicine in many fields. I am genuinely grateful for the opportunities medicine has provided to me and am glad to be a physician and academic faculty. I hope you can find a passion too and not be too worried that your difficulties in doing pharmacokinetics will make you "mediocre."