Renal Carbonic Anhydrase

[JohnDoeDDS]

Could you guys please explain how this works. I'm having trouble understanding this.

if you Inhibit renal carbonic anhydrase.

Aren't you then making the blood more acidic because you can't buffer the CO2?

So I said inhibiting Carbonic Anhydrase will Increase the acidity of Urine. But that is WRONG.

Ans. DECREASE SODIUM resorption in proximal tubule.

I would appreciate it very much. Thanks.

---

Members don't see this ad.

 

[era]

Could you guys please explain how this works. I'm having trouble understanding this.

if you Inhibit renal carbonic anhydrase.

Aren't you then making the blood more acidic because you can't buffer the CO2?

So I said inhibiting Carbonic Anhydrase will Increase the acidity of Urine. But that is WRONG.

Ans. DECREASE SODIUM resorption in proximal tubule.

I would appreciate it very much. Thanks.

IF U INHIBIT RENAL CARBONIC ANHYDRASE,THERE WILL NO H+ TO NEUTRALIZE THE filtered HCO3-
if no H+ will go out into lumen ,no NA+ will be reasorbed Na+/H+ transport.
therefore Na+ reabsorption will decrease.

 

[JohnDoeDDS]

but I thoguht carbonic anhydrase makes CO2 and H2O?

 

[live]

Not positive here... but here's my .02. CA does may CO2 and H20 in one direction... however in the other it makes H+ and bicarbonate. These protons are normally pumped via the "Na/H+ pump/exchanger" into the urine. If you stop the CA system, you will not produce the H+ ions and thus the exhanger won't function as well. So you see a decrese in Na reabsorption. Hope that makes sense and is correct! Check a physio book for sure.