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Steroid hormone vs peptide hormone

Discussion in 'DAT Discussions' started by nt4reall, Jun 21, 2008.

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  1. nt4reall

    nt4reall New Member

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    What's steroid hormone , and what's peptide hormone ? What do we need to know about these hormones for DAT?
    Thanks
  2. DRHOYA

    DRHOYA

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    A major difference between peptide and steroid hormones is the fact that peptide hormones will bind to receptors on the cells they are effecting, and induce a cascading effect. Steroid hormones on the other hand, will travel to the nucleus and have major effects. Insulin is an example of a peptide hormone, and a typical steroid hormone is testosterone. Hope that helps.:thumbup:
  3. nt4reall

    nt4reall New Member

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    Thanks , it helps :laugh:
  4. DentalDeac

    DentalDeac

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    DR HOYA - is the reason that steroids are able to travel directly to the nucleus because they are lipid-soluble and are able to pass through the lipid bilayer membrane of the cell?
  5. 250rsavage

    250rsavage

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    I know this question was for Hoya, but yes, steroid hormones are lipid soluble and is the rest they can interact with the nucleus
  6. DRHOYA

    DRHOYA

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    Right on! Also, ones such as the Glucocorticoids act antagonistcally in regards to insulin.
  7. Dotoday

    Dotoday

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    Hey Guys, steroid hormone does cross the lipid bilayaer because it is hydrophobic, however it also binds to the receptor inside the cytoplasm. This steroid hormone-receptor interaction is what gets steroid into the nucleus and allows it to bind to DNA to initiate transcription. Peptide hormone, like insulin, has charges on it so therefore cannot cross the lipid bilayer by itself and therefore needs to bind to the receptor on the cell membrane and initiate a signaling cascade using GPCRs and cAMP. As thge matter of fact if a molecule has a charge it cannot cross a lipid bilayer by itself.
    Hope this helps.
  8. heidy

    heidy

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    Steroid hormones freely enter their target cells after combining with an intracellular receptor, they exert a direct influence on the transcription of mRNA. They do directly influence the transcription by binding to the DNA of their taget cells and promoting transcription of specific genes.

    Peptide hormones combine with receptor molecules on the surface of their target cells' membrane. These hormones do not influence the transcription of mRNA directly and in other words, peptide hormones do not enter the nucleus of their target cells and activate transcription.
  9. ktran17

    ktran17

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    steroid hormones are lipids and therefore can diffuse through plasma membrane

    the steroid hormone either binds onto a receptor in the cytoplasm or on the nucleus and forms a complex. this complex then goes on and induces increase level of transcription activity.

    Peptide hormones are lipophobic (hydrophilic), usually charged and therefore cannot cross the plasma membrane

    Due to this property, they're receptors are usually found on plasma membrane

    The main thing to get out of peptide hormones is that small amounts of hormone can influence a huge change due to cascade phosphorylation. If you want more information about this mechanism, google G-protein coupled receptor (GPCR) < this is one of the more common peptide hormone mechanism but is not the only type
  10. Stacker

    Stacker n = 1

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    'Flat peg' accronym.
    Fsh, lh, adh, and tsh I think are steroids.
    Ph and gh are peptides i think someone correct me if im wrong.
  11. Davermz450

    Davermz450

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    This is 4 years old....
  12. Jaesango

    Jaesango

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    Sorry for bringing back an old thread but I had to correct this.
    the pituitary gland does not release any steroid hormones. It's all peptide based.
  13. stlrams22

    stlrams22

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    thanks for stating the obvious

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