The prescription opioid epidemic in a nutshell

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I've only just begun. Our specialty has a hell of a lot more penance to do for what we unleased.

Barry Meier's on Dianne Rehm: http://thedianerehmshow.org/shows/2013-09-12/barry-meier-pain-killer

Pain Killer on Amazon: http://www.amazon.com/Pain-Killer-e...F8&qid=1379118261&sr=8-3&keywords=barry+meier

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It is unclear to me why "our specialty" is at fault. The PCPs kill far more patients every year than do pain physicians. That is their debacle, not ours. Notwithstanding PROPs abject failure in achieving any meaningful goals before the FDA (apparently they were not convincing), pain medicine has pushed all of medicine towards enhanced monitoring and the development of guidelines for opioid prescribing. You don't see PCPs crying out for FP academy standards requiring urine toxicology testing or mandatory action being taken on aberrant tests. Nor do PCPs embrace PMPs.....they hate them because it actually requires them to accept just a shred of responsibility before prescribing opioids to patients they have taking a sedative soup.
 
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it is unclear to me why "our specialty" is at fault. The pcps kill far more patients every year than do pain physicians. That is their debacle, not ours. Notwithstanding props abject failure in achieving any meaningful goals before the fda (apparently they were not convincing), pain medicine has pushed all of medicine towards enhanced monitoring and the development of guidelines for opioid prescribing. You don't see pcps crying out for fp academy standards requiring urine toxicology testing or mandatory action being taken on aberrant tests. Nor do pcps embrace pmps.....they hate them because it actually requires them to accept just a shred of responsibility before prescribing opioids to patients they have taking a sedative soup.

+1.
 
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It is unclear to me why "our specialty" is at fault. The PCPs kill far more patients every year than do pain physicians. That is their debacle, not ours. Notwithstanding PROPs abject failure in achieving any meaningful goals before the FDA (apparently they were not convincing), pain medicine has pushed all of medicine towards enhanced monitoring and the development of guidelines for opioid prescribing. You don't see PCPs crying out for FP academy standards requiring urine toxicology testing or mandatory action being taken on aberrant tests. Nor do PCPs embrace PMPs.....they hate them because it actually requires them to accept just a shred of responsibility before prescribing opioids to patients they have taking a sedative soup.

one can argue that "our specialty" has been represented by drug thought leaders - more appropriately, lackeys - that have paid and played a role in encouraging PCPs towards rampant opioid prescribing.

PCPs are blaming pain medicine for irresponsible teaching.

it is only recently, after the CDC openly declared an opioid epidemic, that PROP came out, that some opioid proponents (? Pourtenoy) have changed their tune, that people like Ballantyne are espousing responsible prescribing, that APF is no longer active....
 
There's plenty of blame to go around. Yes, Pain Medicine as a specialty deserves much blame. PCPs deserve much blame. Other specialties who prescribe with little thought as to the consequences deserve blame. Hospitals that cater to the "customer is always right mentality" deserve much blame. Drug companies also have much culpability. Some innocent patients ended up dependent without fully being warned of the addictive potential of opiates.

But ON THE OTHER HAND....

Never, ever, forget the dozens, hundred and thousands of patients, many of whom not only knew the addictive risks of opiates, but lied, manipulated and malingered to get pills to abuse, trade and sell. Many such patients were not, and are not innocent and to this day also bear an equal share of the blame. It is common knowledge for most grown adults, that prescription medications shouldn't be abused and taken other than as directed, just as it is common knowledge gasoline is intended for proper use in a car gas tank, and is not to be huffed and inhaled for euphoria. People don't fall over killing themselves to take grandmas extra blood pressure pills, yet some will rob grandma to take her pain pills for her cancer pain. Is this by coincidence? There is no ulterior motive? Is this because they don't know the difference between a blood pressure pill and an opiate? Is it always because some rouge doctor tricked them into doing it?

They have no culpability whatsoever in this "epidemic"?

They absolutely do.

I'm relatively new to the field of Pain Medicine as a sub-specialist, in the past 2 years. In the years prior to that, I spent a portion of my to work time trying to stop the "bleeding" of this epidemic on the front lines, pushing narcan, passing ET tubes, notifying families and committing patients to detox who had hit rock bottom, while listening to the words of the "thought leaders" preaching "Prescribe more opiates! There is no ceiling dose!" ring in the background.

Now I practice Pain Medicine full-time trying to repair the damage, one patient at a time, while still effectively treating pain. We are all in this together; doctors, patients, hospitals and drug companies alike, and we all have responsibility in fixing the problem.
 
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Remember Ballantyne also flip flopped after she developed nationally recognized opioid guidelines for prescribing. Yes there is much culpability from the past but pain medicine is absolutely not driving the contiuation of the epidemic now
 
Remember Ballantyne also flip flopped after she developed nationally recognized opioid guidelines for prescribing. Yes there is much culpability from the past but pain medicine is absolutely not driving the contiuation of the epidemic now

For the vast majority, that is right... But as long as there are Fines, Tennants, etc out there, there will still be a negative perception. It will take years to marginalized their opinions, since it has been so ingrained...
 
Russel Portenoy is a member of PROMT, but he should be in jail. I hope the Senate has the will to act.

Algos, our thought leaders sold out for $. You and I share their stain. The list of our elders who either sold out or mislead PMD's is just shameful.
 
I guess I see pain medicine as a victim to the hyperbole of drug manufacturers as much as family medicine. The difference at this point is that pain medicine is doing something about it. I wonder how many consider Forrest a leader past and present.....egads!!!!
 
Clearing up a common the misconception held by many pain specialistis: Methadone & Buprenorphine simply substitute one addiction for another.

http://www.drugabuse.gov/sites/default/files/podat_1.pdf

Is the use of medications like methadone and buprenorphine simply replacing one addiciton with another?

No. Buprenorphine and methadone are prescribed or administered under monitored, controlled conditions and are safe and effective for treating opioid addiction
when used as directed. They are administered orally or sublingually (i.e., under the tongue) in specified doses, and their effects differ from those of heroin and other abused opioids.

Heroin, for example, is often injected, snorted, or smoked, causing an almost immediate "rush," or brief period of intense euphoria, that wears off quickly and ends in a "crash." The individual then experiences an intense craving to use the drug again to stop the crash and
reinstate the euphoria.

The cycle of euphoria, crash, and craving—sometimes repeated several times a day—is a hallmark of addiction and results in severe behavioral disruption. These characteristics result from heroin’s rapid onset and short duration of action in the brain.

As used in maintenance treatment, Methadone and Buprenorphine are not heroin/opioid substitutes.

In contrast, methadone and buprenorphine have gradual onsets of action and produce stable levels of the drug in the brain. As a result, patients maintained on these
medications do not experience a rush, while they also markedly reduce their desire to use opioids.

If an individual treated with these medications tries to take an opioid such as heroin, the euphoric effects are usually dampened or suppressed. Patients undergoing maintenance treatment do not experience the physiological or behavioral abnormalities from from rapid fluctuations in drug levels associated with heroin use. Maintenance treatments save lives—they help to stabilize individuals, allowing treatment of their medical, psychological, and other problems so they can contribute effectively as members of families and of society.
 
The above is patently false and shows what rubbish is published by the government. Methadone and buprenorphine are indeed simply substitutes for any opioid narcotic. The idea that addiction is cured by these drugs is laughable....they are still addicted, only now to a new drug. They stop methadone or buprenorphine and they immediately go back to other opioids. Besides, there is a 30-50% recidivism rate while taking methadone or buprenorphine. If there were indeed great treatments for addiction, then the recidivism rate would be zero. Methadone and buprenorphine do save lives for those taking heroin, but they are simply substitution....no different than morphine substituting for opium in the mid to late 1800s and heroin substituting as a treatment for morphine addiction in the late 1800s and early 1900s. Methadone has a 10 times higher death rate than any other opioid, therefore it can hardly be argued it is unequivocally safer than other opioids....it is only safer than IV heroin.
 
Clearing up a common the misconception held by many pain specialistis: Methadone & Buprenorphine simply substitute one addiction for another.

http://www.drugabuse.gov/sites/default/files/podat_1.pdf

Is the use of medications like methadone and buprenorphine simply replacing one addiciton with another?

No. Buprenorphine and methadone are prescribed or administered under monitored, controlled conditions and are safe and effective for treating opioid addiction
when used as directed. They are administered orally or sublingually (i.e., under the tongue) in specified doses, and their effects differ from those of heroin and other abused opioids.

Heroin, for example, is often injected, snorted, or smoked, causing an almost immediate "rush," or brief period of intense euphoria, that wears off quickly and ends in a "crash." The individual then experiences an intense craving to use the drug again to stop the crash and
reinstate the euphoria.

The cycle of euphoria, crash, and craving—sometimes repeated several times a day—is a hallmark of addiction and results in severe behavioral disruption. These characteristics result from heroin’s rapid onset and short duration of action in the brain.

As used in maintenance treatment, Methadone and Buprenorphine are not heroin/opioid substitutes.

In contrast, methadone and buprenorphine have gradual onsets of action and produce stable levels of the drug in the brain. As a result, patients maintained on these
medications do not experience a rush, while they also markedly reduce their desire to use opioids.

If an individual treated with these medications tries to take an opioid such as heroin, the euphoric effects are usually dampened or suppressed. Patients undergoing maintenance treatment do not experience the physiological or behavioral abnormalities from from rapid fluctuations in drug levels associated with heroin use. Maintenance treatments save lives—they help to stabilize individuals, allowing treatment of their medical, psychological, and other problems so they can contribute effectively as members of families and of society.

Dumbest siht ever posted on this forum. Maybe thr whole interweb.
 
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Thank you Drs. Laurel & Hardy for another thoughtful rebuttle to the research of Nora Volkow, NIDA, NIH, & SAMHSA.
 
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Don't care who it is, or what government soup they work for. Real doctors in real clinical situations know the difference between rat studies and human behavior concerning opioids. The idea that these are not substitution is so nonsensical that it defies logic. If it is not substitution, then why is there massive withdrawal from methadone? Or even suboxone? The opioid receptors don't care if they are occupied by hydrocodone or heroin....these addicts need them occupied by something that substitutes for another opioid.
 
You tell the methadone that its not for pain, its only to prevent heroin or oxycodone use. And it listens.

101n: Go watch Methadonia. It was an HBO special.

Pure agonist replacing pure agonist. Only benefit is head to head against heroin due to purity and no dirty needles.
 
I think a point is being missed... I agree with both sides.

Addiction specialists are definitely replacing opioids by using meth and suboxone. These alone do not treat the addiction. It's the psychological counseling that treats the addiction, as much as it can be treated... More like managed.

I equate it up being like any chronic BP med or diabetic med. is the med "treating" the condition? No... It's to reduce potential side effects. Weight loss , lifestyle changes, dietary changes, exercise, etc. are "treatments"
 
My objection is with the addictionologist claiming they are not substituting one opioid for another. This is as ludicrous as claiming opioids are not addictive. Perhaps Volkow is the addictionologists equivalent to Tennant or Portnoy
 
Never, ever, forget the dozens, hundred and thousands of patients, many of whom not only knew the addictive risks of opiates, but lied, manipulated and malingered to get pills to abuse, trade and sell. Many such patients were not, and are not innocent and to this day also bear an equal share of the blame.

I think these patients are completely under counted in statistics. For every flagrant raging drug abuser, I think there are multiple others who have a recreational drug habit but are high functioning. They work, they pay their bills and they regularly use opiates like others have a beer or cocktail. They're very hard to catch because they say the right things, throw a few red flags but nothing awful (e.g. early refill by a few days once in a while, refuse procedures or surgery citing risk or finances, say they're doing PT exercises which you could never prove), their PDMP is appropriate, etc. etc.

Just check www.bluelight.ru or forum.opiophile.org and see how many posts allude to "I'm very careful to not mess up with my pain doctor because I don't want to ruin a good thing."
 
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http://www.ncbi.nlm.nih.gov/pubmed/22845054

Pain Med. 2012 Sep;13(9):1162-73. doi: 10.1111/j.1526-4637.2012.01450.x. Epub 2012 Jul 30. A model to identify patients at risk for prescription opioid abuse, dependence, and misuse. Rice JB, White AG, Birnbaum HG, Schiller M, Brown DA, Roland CL.
SourceAnalysis Group, Inc., Boston, MA 02199, USA. [email protected]

Abstract
OBJECTIVE:
The objective of this study was to use administrative claims data to identify and analyze patient characteristics and behavior associated with diagnosed opioid abuse.

DESIGN:
Patients, aged 12-64 years, with at least one prescription opioid claim during 2007-2009 (n = 821,916) were selected from a de-identified administrative claims database of privately insured members (n = 8,316,665). Patients were divided into two mutually exclusive groups: those diagnosed with opioid abuse during 1999-2009 (n = 6,380) and those without a diagnosis for opioid abuse (n = 815,536). A logistic regression model was developed to estimate the association between an opioid abuse diagnosis and patient characteristics, including patient demographics, prescription drug use and filling behavior, comorbidities, medical resource use, and family member characteristics. Sensitivity analyses were conducted on the model's predictive power.

RESULTS:
In addition to demographic factors associated with abuse (e.g., male gender), the following were identified as "key characteristics" (i.e., odds ratio [OR] > 2): prior opioid prescriptions (OR = 2.23 for 1-5 prior Rxs; OR = 6.85 for 6+ prior Rxs); at least one prior prescription of buprenorphine (OR = 51.75) or methadone (OR = 2.97); at least one diagnosis of non-opioid drug abuse (OR = 9.89), mental illness (OR = 2.45), or hepatitis (OR = 2.36); and having a family member diagnosed with opioid abuse (OR = 3.01).

CONCLUSIONS:
Using medical as well as drug claims data, it is feasible to develop models that could assist payers in identifying patients who exhibit characteristics associated with increased risk for opioid abuse. These models incorporate medical information beyond that available to prescription drug monitoring programs that are reliant on drug claims data and can be an important tool to identify potentially inappropriate opioid use.
 
https://www2.gotomeeting.com/register/802566154

Naloxone Rescue Kits (APA)
Overdose is a leading cause of preventable death in the United States and increasing in the setting of wider access to prescription opioids. Yet education about overdose prevention and management is not routinely integrated into medical or addiction treatment settings. Evidence is emerging that overdose education and naloxone rescue kit distribution can reduce overdose death rates and is highly cost-effective.

At the end of this session, participants will be able to (1) Understand the epidemiology and natural history of opioid overdose, (2) Explain existing prevention efforts, specifically models for providing overdose education and naloxone rescue kits, (3) Review the evidence for overdose education and naloxone rescue kits, and (4) Know the facilitators and barriers to incorporating overdose prevention education and prescribing naloxone rescue kits into their practice.

All participants should be able to incorporate overdose prevention education into their practices and many should be able to prescribe naloxone rescue kits to patients.

The webinar is sponsored by the American Psychiatric Association as a partner organization in the Prescribers' Clinical Support System-Opioid Therapies (PCSS-O).
 
https://www2.gotomeeting.com/register/802566154

Naloxone Rescue Kits (APA)
Overdose is a leading cause of preventable death in the United States and increasing in the setting of wider access to prescription opioids. Yet education about overdose prevention and management is not routinely integrated into medical or addiction treatment settings. Evidence is emerging that overdose education and naloxone rescue kit distribution can reduce overdose death rates and is highly cost-effective.

At the end of this session, participants will be able to (1) Understand the epidemiology and natural history of opioid overdose, (2) Explain existing prevention efforts, specifically models for providing overdose education and naloxone rescue kits, (3) Review the evidence for overdose education and naloxone rescue kits, and (4) Know the facilitators and barriers to incorporating overdose prevention education and prescribing naloxone rescue kits into their practice.

All participants should be able to incorporate overdose prevention education into their practices and many should be able to prescribe naloxone rescue kits to patients.

The webinar is sponsored by the American Psychiatric Association as a partner organization in the Prescribers' Clinical Support System-Opioid Therapies (PCSS-O).

Call me heartless, but I'm against this idea. Any patient for whom you're so worried they're going to overdose that you need to give them naloxone rescue kits is not a good candidate for opioids.

Narcotic treatment is not a constitutional right. I warn all of my patients of the risks and particularly stress that they don't have the option to take more than prescribed. I also stress the medication is to improve function. Eliminating every ounce of pain is not gonna happen. If they don't listen to me and swallow half their entire bottle, that's darwinism at work. However, anyone for whom I worry about that happening..................is not a opioid candidate.

People wanting to stupefy themselves with opioids, are demented, on 30 medications and sensitive to everything, felons, chemical copers, etc aren't candidate for opioids. They get nothing from me.

There is such a sense of entitlement in america. I don't recall the exact statistic, but I believe we consume 95% of with worlds opioids, despite having 15% of the worlds population.

Giving out naloxone rescue kits is will only encourage more opioid misuse, and further the entitled attitude of US patients.
 
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Two groups of patients that will benefit from this are legacy patients who have been started in this medication - by our peers from previously - who are naturally aging and developing chronic illnesses etc, and those requiring fairly rapid titration of these medications - ie cancer pain patients undergoing aggressive chemo.

Maybe you don't take care of these types of patients...


Remember also that the majority of overdoses are not intentional but more a result of unintentional polypharmacy mixed with other illnesses leading to mental status changes.
 
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/

In other words, the 100 million is a gross exaggeration that is being used
by PHARMA and pain adovcacy groups to further their causes: opioids & $.
The actual number is closer to 33M.

In this issue, a survey of the adult population of Portugal
provides a refined understanding of the significance of
chronic pain in the population at large, and how it is cared
for. The overall estimate of chronic pain prevalence (37%) is
similar to that used by the IOM report on chronic pain, and to
chronic pain prevalence estimates observed in other countries
worldwide.3 However, this report clarified the overall
estimate of chronic pain prevalence by differentiating the
11% of the adult population with moderate to severe chronic
pain from the 26% with less severe chronic pain. In other
words, roughly two thirds of those with chronic pain in this
study had relatively mild chronic pain conditions for which
self-management is likely to be the safest and most cost effective
alternative.
 
but I believe we consume 95% of with worlds opioids, despite having 15% of the worlds population.

Someone on SDN said 80% of the world's opioids with 5% of the population. The estimate right now is that the US has 4.45% of the world's population - 1/3 of what you were stating. I think that that is even more stark (no matter whether 80% or 95%).
 
But there are not 33 million people in the US receiving chronic daily opioids even though they have severe pain......
 
we clearly consume 95% of the worlds hydrocodone.

in several countries, it is not available. according to wikipedia, in some countries like the Netherlands and UK, it is illegal.

and in the US, its a Schedule III with refills available. go figure.
 
But there are not 33 million people in the US receiving chronic daily opioids even though they have severe pain......

No, there are probably closer to 100 million people receiving opioids in the US.
For their hang-nails, hemorrhoids, & restless leg syndrome.
 
in some countries like the Netherlands and UK, it is illegal.

I rotated through a London hospital during my 4th year of medical school for 5 weeks. I was stunned at how little narcotics were dispensed, even for post-operative cases (one was a BKA). These patients did not look any more uncomfortable compared to the ones I see today. If anything, they were more coherent and less lethargic.
 
http://cironline.org/reports/va’s-o...ons-overdose-deaths-5261#.UlGiAZHLNEM.twitter

Before dawn, a government van picked up paratrooper Jeffrey Waggoner for the five-hour drive to a Department of Veterans Affairs hospital in southern Oregon. His orders: detox from a brutal addiction to painkillers.

He had only the clothes on his back, his watch, an MP3 player and a two-page pain contract the Army made him sign, a promise to get clean.

But instead of keeping Waggoner away from his vice, medical records show the VA hospital in Roseburg kept him so doped up that he could barely stay awake. Then, inexplicably, the VA released him for the weekend with a cocktail of 19 prescription medications, including 12 tablets of highly addictive oxycodone.

Three hours later, Waggoner, 32, was dead of a drug overdose, slumped in a heap in front of his room at the Sleep Inn motel.

“As a parent, you’d want to know how this happened to your child,” said his father, Greg Waggoner. “You send your child to a hospital to get well, not to die.”

Jeffrey Waggoner’s end and easy access to the narcotics that killed him have become tragically common, The Center for Investigative Reporting has found.

Since the 9/11 terrorist attacks, the agency charged with helping veterans recover from war instead masks their pain with potent drugs, feeding addictions and contributing to a fatal overdose rate among VA patients that is nearly double the national average.

Prescriptions for four opiates – hydrocodone, oxycodone, methadone and morphine – have surged by 270 percent in the past 12 years, according to data CIR obtained through the Freedom of Information Act. CIR’s analysis for the first time exposes the full scope of that increase, which far outpaced the growth in VA patients and varied dramatically across the nation.

Waggoner was among the victims of the VA prescription epidemic.

Unemployed and newly divorced, he had joined the Army for a fresh start in 2006. After a rocket-propelled grenade blast in Afghanistan sent shockwaves through his 6-foot frame, though, he got hooked on government-issued painkillers; mentally, he never recovered.

Waggoner told a nurse at the Roseburg VA hospital that he suffered from severe flashbacks that made him cry out in the middle of the night, strangling his pillow, hitting the wall. He sleepwalked, sometimes jolting awake in his closet, still battling the Taliban in the Korengal Valley of his mind.

The VA responded with a battery of drugs so generous that in the weeks leading up to Waggoner’s overdose, his medical records show, he woke only to take his medicine.

“When not stimulated, (he) lies on the gurney and rapidly falls asleep,” Dr. Donald J. Venes noted 10 days before Waggoner’s release. Nurse Larry Reeves wrote that Waggoner’s “eyes were just slits and he appeared to be overly sedated.” He was rushed to the emergency room after falling out of bed.

In the last three hours of his life, Waggoner checked into a motel near the hospital and drank two bottles of beer. He took eight oxycodone tablets, together with a fistful of tranquilizers and muscle relaxants – all courtesy of the VA.

When he fell asleep at the counter of a nearby Applebee’s while having nachos and another beer, the restaurant manager helped him back to the motel.

There, Waggoner stumbled down the hallway, fumbled with his room key and collapsed face down onto the carpeted floor. Surveillance video shows other motel guests stepped over him for an hour.

By the time paramedics arrived, it was too late.

Rising prescription rate


Waggoner died in 2008. Since then, the VA’s opiate prescription rate has continued to rise and across the country, veterans are locked in a life-and-death struggle, addicted to painkillers they got from the VA.

The data shows the agency has issued more than one opiate prescription per patient, on average, for the past two years. In interviews, advocates and experts said the skyrocketing prescription rate confirmed their worst fears: that the agency is overmedicating its patients as it struggles to keep up with their need for more complex treatment.

“Giving a prescription, which they know how to do and are trained to do, is almost a default,” said Dr. Stephen Xenakis, a psychiatrist and retired brigadier general who served as commanding general of the Army’s Southeast Regional Medical Command.

The problem, Xenakis said, is that opiates hurt more veterans than they help.

Senior VA officials declined to be interviewed about the prescription epidemic. Instead, the agency produced a written statement saying it was engaged “in multiple, ongoing efforts to address prescription drug abuse among veterans seen in our healthcare system.”

The agency long has been aware of the problem. In 2009, new VA regulations required clinicians to follow an “integrated approach” to helping veterans in pain, including a stronger focus on treating the root causes of pain rather than using powerful narcotics to reduce symptoms.

But despite the regulations, VA doctors are prescribing more opiates than ever and the data suggests that adoption of the regulations varies wildly.

Last year, for example, doctors at the VA hospital in rural southern Oregon where Jeffrey Waggoner was treated prescribed eight times as many opiates per patient as their colleagues at the VA hospital in Manhattan.

“The VA is very segmented, very siloed, and you have a lot of fiefdoms where hospital directors are just running their own show out there,” said Tom Tarantino, a former Army captain and chief policy officer for the advocacy group Iraq and Afghanistan Veterans of America.

To Greg Waggoner, the variation suggests local hospital officials can act with impunity. “They basically have a blank check,” he said. “We need better control and people need to be held responsible.”

‘I knew one of us was going to die’

Late at night, Tim Fazio sits on the floor of his sparsely furnished apartment in Newport, N.H., watching YouTube videos over and over again of “One Day,” a call for peace by Jewish reggae artist Matisyahu. He prefers the night, without the loud noises that trigger his post-traumatic stress disorder.

“One Day” was the favorite song of his friend and former roommate Eric Demetrion, a fellow U.S. Marine Corps veteran who died of a drug overdose June 1 at 33.

Fazio met Demetrion at the VA psychiatric ward in Northampton, Mass., and the two lived together until March, feeding each other’s addiction to oxycodone and other prescription painkillers. When they couldn’t get enough opiates legally, they bought heroin – their apartment was an unkempt wasteland of pill bottles and syringes.

They ate only when Fazio’s girlfriend, Jennifer Reed, drove down with a car full of steak, sausages and other favorite foods, which she cooked for them. Reed begged Fazio to leave Demetrion and move in with her, she said, and eventually he agreed.

“I knew one of us was going to die,” said Fazio, who served in Iraq and Afghanistan before being honorably discharged in 2006.

Now, he blames himself for Demetrion’s death, believing he abandoned a Marine in need, violating the unwritten battlefield code of ethics.

“I know that’s a cowardly way out, leaving my buddy behind,” he said. “Being an addict is selfish anyway.”

Fazio’s medical records underscore how the VA deals with patients in pain – both physical and mental.

He started getting opiates from the VA in 2008, two years after he left the Marines. Since then, the agency has provided him with nearly 4,000 oxycodone pills and more than a dozen bottles of tramadol, another opioid painkiller.

He says he never has been in serious physical pain but instead has used the opiates to blot out feelings of guilt for surviving when so many of his close friends have not. On his bookcase, he keeps a photograph of four Marine Corps buddies: One killed himself, another was found decomposing in a Florida ditch after battling painkiller addiction and PTSD, and a third was charged with murder.

Fazio’s medical diagnoses include PTSD, traumatic brain injury and anxiety, conditions for which opiates hinder recovery, studies show. Yet the VA’s scientists report that the agency’s doctors regularly prescribe opiates to these patients anyway.

Last year, researchers at the San Francisco VA Medical Center published a paper in the Journal of the American Medical Association that found VA doctors prescribed significantly more opiates to patients with PTSD and depression than to other veterans – even though people suffering from those conditions are most at risk of overdose and suicide.

Researchers at the agency’s Health Services Research and Development Service reported in 2011 that veterans seen by the agency’s doctors were dying from prescription drug overdoses at nearly twice the national average.

“Opiates have an adverse effect for most of these patients,” Xenakis said. “They make sleep more difficult, because they disrupt your usual sleep patterns, and as your sleep gets worse, your mood and your anxiety gets worse, and you find yourself not being able to think as clearly.”

And opiates are a downer, Xenakis said, so they tend to make depressed veterans more depressed.

Despite addiction, prescriptions continued

Photographs from Fazio’s childhood show a charismatic athlete, the well-muscled captain of his high school hockey team in the small town of Clinton, Mass.

Today, he is a wreck, his eyes sunken in, his once-bulky arms atrophied. Sometimes, days go by when he doesn’t leave the house. With his mind no longer deadened by opiates, his PTSD symptoms have rushed to the fore. Flashbacks and anxiety make him angry and explosive.

“I feel like he’s starting to understand where things are coming from and somewhat how to deal with them,” said Reed, his girlfriend. “I don’t think he’s ever been at this point before, because he’s always masked it with pills or whatever he could get.”

It’s been a struggle to stay clean. Not only is Fazio wrestling with emotions previously numbed by oxycodone and heroin, but he’s also fighting a VA system in which doctors keep prescribing opiates even though his electronic health record shows he is trying to kick an addiction.

Hospital records indicate that the VA knew Fazio was an addict back in 2009 – and provided detox. But the agency’s doctors continued to prescribe oxycodone for three more years, until his parents hired a lawyer and threatened to sue the agency for medical malpractice.

“It’s so sick. It’s so wrong,” said his mother, Kathy Fazio. “The kid is flagged everywhere with what he’s addicted to, and they’re still giving him Percocets. He’s better off to the Veterans Administration dead than … paying all that money to help him.”

As recently as July 29, after a fight with four other men over his girlfriend landed Fazio in the emergency room, a physician at the VA in White River Junction, Vt., gave him a morphine drip – and sent him on his way with a prescription for 30 tablets of oxycodone.

Fazio filled the prescription and sat in his apartment, staring at the bottle.

“I opened it up a couple of times a day for three or four days to take one out,” but never swallowed one, he said.

Even as his addiction screamed for a pill, he told himself, “If I take this, I’m not going to be living where I am now. I’m going to be off and running again.”

So he flushed them down the toilet.

Wave of opiates in Oklahoma

Since the 9/11 attacks, no VA hospital system has prescribed more opiates per patient than the Jack C. Montgomery VA Medical Center in Muskogee, Okla. Over the past decade, the hospital and its clinic in Tulsa issued 1.6 opiate prescriptions per patient.

The results can be seen in Tulsa’s jail and in its criminal courthouse, which has called a special docket for veteran offenders every Monday since December 2008.

Observers say geography is a contributing factor. The VA hospital in Muskogee is an hour’s drive from the region’s main population center in Tulsa. And the VA’s single-story clinic in Tulsa has no emergency room or urgent care ward and rarely makes same-day appointments.

Veterans who need treatment for the root causes of pain often wait months, said Craig Prosser, who coordinates the court’s mentor program.

“If I have to wait 30 days, 45, all the way up to 90 days to be able to get seen by my doctor, I’m probably going to go out and try to find something to deal with the pain prior to,” Prosser said.

The region’s opiate prescription rate has dropped slightly in the past year, and Prosser credits a new director of the Muskogee VA for expanding services. The VA would not allow the hospital director, James R. Floyd, to be interviewed.

It’s 100 degrees and humid outside as dozens of veterans file into the first-floor courtroom of Judge Rebecca Nightingale, who presides over Tulsa’s Veterans Treatment Court. Prosser greets each of them individually and goes over their treatment, slapping them on the back and occasionally giving one a hug.

“They don't know who they are anymore; they lost their self-identity,” said Prosser, who served two tours in Iraq with the Army’s 101st Airborne Division. “What I want to do is help them find that, help to find their … true north, as we say in the infantry.”

On this August afternoon, they range from elderly Vietnam veterans who’ve pleaded guilty to possession of methamphetamines to an Iraq War veteran who beat his girlfriend so brutally that her eyes swelled shut.

John Cloud, a Vietnam veteran who is the American Legion’s liaison to the court, describes a troubling pattern among Iraq and Afghanistan veterans arrested in Tulsa. It starts in the military, after injuries from an explosion or enemy fire leads to a prescription for Vicodin or oxycodone, he said, and then continues at the VA.

Eventually, Cloud said, the veteran builds up a tolerance. The VA’s prescriptions are not enough, so “they’ll go to the streets and buy the drugs, turn to alcohol” and cheat and steal to get money to feed their habit.

A bearded man in a denim jacket drags his right leg as he approaches the judge. Chance Oswalt has been struggling with painkiller addiction since 2007, when the Army prescribed Percocet after he was wounded in Baghdad.

Last Christmas Eve, police found Oswalt passed out in Room 906 at the Marriott Tulsa Hotel Southern Hills, surrounded by syringes, spoons and other drug paraphernalia, with a black rock of heroin on the nightstand.

Since the arrest, Oswalt hasn’t tested positive for heroin while participating in the VA’s court-mandated pain management program. But he has continued to doctor-shop, driving 100 miles to a private physician near the Arkansas border for oxycodone.

During the hearing, the judge remains relentlessly upbeat, telling veterans they have the power to stay clean. Nightingale reassures them that they are not to blame for their addictions. She tells Oswalt: “You wouldn’t have chosen to take all those medications,” and he agrees.

“It was just a last resort,” he said. Now, “I’m trying to make the program work for me and see if I can get better.”

Officials in Tulsa take pride in their program – more than 90 percent of veterans who enter the treatment court graduate. Very few have re-offended.

But Nightingale knows the stark facts: For every veteran who graduates, another enters the criminal justice system.

The most difficult thing about breaking the cycle of veterans’ painkiller addiction, she said, is that most are hooked on a legal drug. Even when they supplement their prescriptions with pills or other drugs bought on the street, psychologically, they find it “easy to fall back on, ‘Oh, my doctor said it’s OK.’ ”

Senior data reporter Agustin Armendariz contributed to this story. It was edited by Amy Pyle and copy edited by Nikki Frick and Christine Lee.
 
and in the US, its a Schedule III with refills available. go figure.
NY recently made all hydrocodone containing meds (vicodin, lortab, norco, etc) C-II.

Ultram and Soma were made C-IV
 
Systematic Literature Review and Meta-Analysis of the Efficacy and Safety of Prescription Opioids, Including Abuse-Deterrent Formulations, in Non-Cancer Pain Management.

Michna E, Cheng WY, Korves C, Birnbaum H, Andrews R, Zhou Z, Joshi AV, Schaaf D, Mardekian J, Sheng M.

Pain Med. 2013 Sep 23.[Epub ahead of print]
Source: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.


OBJECTIVE: This study was conducted to compare safety and efficacy outcomes between opioids formulated with technologies designed to deter or resist tampering (i.e., abuse-deterrent formulations [ADFs]) and non-ADFs for commonly prescribed opioids for treatment of non-cancer pain in adults.

METHODS: PubMed and Cochrane Library databases were searched for opioid publications between September 1, 2001 and August 31, 2011, and pivotal clinical trials from all years; abstracts from key pain conferences (2010-2011) were also reviewed. One hundred and ninety-one publications were initially identified, 68 of which met eligibility criteria and were systematically reviewed; a subset of 16 involved a placebo group (13 non-ADFs vs placebo, 3 ADFs vs placebo) and reported both efficacy and safety outcomes, and were included for a meta-analysis. Summary estimates of standardized difference in mean change of pain intensity (DMCPI), standardized difference in sum of pain intensity difference (DSPID), and odds ratios (ORs) of each adverse event (AE) were computed through random-effects estimates for ADFs (and non-ADFs) vs placebo. Indirect treatment comparisons were conducted to compare ADFs and non-ADFs.

RESULTS: Summary estimates for standardized DMCPI and for standardized DSPID indicated that ADFs and non-ADFs showed significantly greater efficacy than placebo in reducing pain intensity. Indirect analyses assessing the efficacy outcomes between ADFs and non-ADFs indicated that they were not significantly different (standardized DMCPI [0.39 {95% confidence interval (CI) 0.00-0.76}]; standardized DSPID [-0.22 {95% CI -0.74 to 0.30}]). ADFs and non-ADFs both were associated with higher odds of AEs than placebo. Odds ratios from indirect analyses comparing AEs for ADFs vs non-ADFs were not significant (nausea, 0.87 [0.24-3.12]; vomiting, 1.54 [0.40-5.97]; dizziness/vertigo, 0.61 [0.21-1.76]; headache, 1.42 [0.57-3.53]; somnolence/drowsiness, 0.47 [0.09-2.58]; constipation, 0.64 [0.28-1.49]; pruritus 0.41 [0.05-3.51]).

CONCLUSION: ADFs and non-ADFs had comparable efficacy and safety profiles, while both were more efficacious than placebo in reducing pain intensity.

PMID: 24112715
 
It is at least as evidence based as injecting steroids instead of saline in epidural injections....on a harm reduction model with equivalency in results, we should all abandon epidural steroids in favor of saline injections. Will that happen? Probably not. At least until the insurers figure this out. Point is: you demand to live by EBM then you will also die by EBM.
While there will certainly be tragic stories of OD from overprescribing of opioids, it is equally true, even in the VA studies, that vets engage in substance abuse resulting in overdosing. In the VA study, those being prescribed zero opioids were also overdosing and dying with opioids on board. Definitely some VAs were engaging in completely out of control prescribing and the lack of follow up visits is criminal (mailing out schedule II scripts- no one should routinely mail out Schedule II scripts without some follow up). It appears the VA system is indeed broken. Even though the VA is supposed to be placing prescribing data in the PMPs, they refuse to do so in my state. Another federal agency gone rogue, failing to live up to their obligations under the law.
 
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http://journals.lww.com/journaladdi..._Safety_of_Benzodiazepines_and_Opioids.8.aspx

Comparative Safety of Benzodiazepines and Opioids Among Veterans Affairs Patients With Posttraumatic Stress Disorder
Hawkins, Eric J. PhD; Malte, Carol A. MSW; Grossbard, Joel PhD; Saxon, Andrew J. MD; Imel, Zac E. PhD; Kivlahan, Daniel R. PhD

Collapse BoxAbstract
Objectives: Although Veterans Affairs (VA) patients with posttraumatic stress disorder (PTSD) are prescribed benzodiazepines and opioids in addition to recommended pharmacotherapies, little is known about the safety of these medications. This study compared the 2-year incidence of adverse events among VA patients with PTSD exposed to combinations of selective serotonin reuptake inhibitors (SSRIs) or serotonin/norepinephrine reuptake inhibitors (SNRIs), benzodiazepines, and opioids.

Methods: This retrospective cohort study used VA administrative data from 2004 to 2010 to identify and follow 5236 VA patients with PTSD with new episodes of (1) SSRIs/SNRIs only; (2) concurrent SSRIs/SNRIs and benzodiazepines; and (3) concurrent SSRIs/SNRIs, benzodiazepines, and opioids. Outcome measures were the 2-year incidence and adjusted hazard ratios (AHR) of mental health and medicine/surgery hospitalizations, emergency department visits, harmful events (eg, injuries and death), and any adverse event after adjustment for demographics, clinical covariates, and adverse event history.

Results: Compared with SSRIs/SNRIs only, the adjusted risk of mental health hospitalizations (AHR: 1.87; 95% confidence interval [CI]: 1.37–2.53) was greater among patients prescribed SSRIs/SNRIs and benzodiazepines concurrently. The AHR of mental health hospitalizations (AHR: 2.00; 95% CI: 1.35–2.98), medicine/surgery hospitalizations (AHR: 4.86; 95% CI: 3.30-7.14), emergency department visits (AHR: 2.01; 95% CI: 1.53–2.65), any harmful event (2.92; 95% CI: 2.21–3.84), and any adverse event (AHR: 2.65; 95% CI: 2.18–3.23) were all significantly greater among patients prescribed SSRIs/SNRIs, benzodiazepines, and opioids than among those prescribed SSRIs/SNRIs only.

Conclusions: Concurrently prescribing SSRIs/SNRIs, benzodiazepines, and opioids among patients with PTSD is associated with adverse events. Although efforts are warranted to monitor patients who are prescribed combinations of these medications to prevent adverse events, these results should be interpreted with caution until they are replicated.
 
http://www.nytimes.com/2013/10/25/b...scriptions-for-class-of-painkillers.html?_r=0

The Food and Drug Administration on Thursday recommended tighter controls on how doctors prescribe the most commonly used narcotic painkillers.

The move, which represents a major policy shift, follows a decade-long debate over whether the widely abused drugs, which contain the narcotic hydrocodone, should be controlled as tightly as more powerful painkillers such as OxyContin.

The drugs at issue contain a combination of hydrocodone and an over-the-counter painkiller like acetaminophen or aspirin and are sold either as generics or under brand names like Vicodin or Lortab. Doctors use the medications to treat pain from injuries, arthritis, dental extractions and other problems.

The change would reduce the number of refills patients could get before going back to see their doctor. Patients would also be required to take a prescription to a pharmacy, rather than have a doctor call it in.

Dr. Janet Woodcock, director of the agency’s center for drug evaluation and research, said she expected the new regulations could take effect as early as next year. The recommendation requires the approval of the Department of Health and Human Services and adoption by the Drug Enforcement Administration, which has been pushing for the measure.

For years, F.D.A. officials had rejected recommendations from the D.E.A.and others for stronger prescribing controls as a way to curb abuse of the drugs, saying the action would create undue hardships for patients. A number of doctors’ groups, including the American Medical Association and pharmacy organizations, have continued to fight the measure, citing the impact on patients.

In a telephone interview, Dr. Woodcock said that F.D.A. officials were aware that changing the prescribing rules would affect patients. She said, however, that the impact on public health caused by the abuse of the drugs as well as their medical use had reached a tipping point.

The new regulations would reduce by half, to 90 days, the supply of the drug a patient could obtain without a new prescription.

Currently, a patient can refill a prescription for such drugs five times over a six-month period before needing a new prescription.

“These are very difficult tradeoffs that our society has to make,” said Dr. Woodcock. “The reason we approve these drugs is for people in pain. But we can’t ignore the epidemic on the other side.”

Concerns continue about the huge number of overdoses involving prescription painkillers as a result of a boom in the use of such drugs over the last decade. Drugs containing hydrocodone frequently make their way onto the street, in part because they are easier to obtain than other narcotics.

The F.D.A. recommendation could have a significant impact on the availability of the drugs.

In 2011, about 131 million prescriptions for hydrocodone-containing medications were written for some 47 million patients, according to government estimates. That volume of prescriptions amounts to about five billion pills.

Technically, the change involves the reclassification of hydrocodone-containing painkillers as “Schedule II” medications from their current classification as “Schedule III” drugs. The scheduling system, which is overseen by the D.E.A., classifies drugs based on their medical use and their potential for abuse and addiction.

Schedule II drugs are those drugs with the highest potential for abuse that can be legally prescribed. The group includes painkillers like oxycodone, the active ingredient in OxyContin, methadone and fentanyl as well as medications like Adderall and Ritalin, which are prescribed for attention-deficit hyperactivity disorder, or ADHD.

In recent years, the question of whether to tighten prescribing controls over hydrocodone-containing drugs has been the subject of intense lobbying.

Last year, for example, lobbyists for druggists and chain pharmacies mobilized to derail a measure passed in the Senate that would mandate the types of restrictions that the F.D.A. is now recommending.

At the time, the lobbying arm of the American Cancer Society also said that making patients see doctors more often to get prescriptions would impose added burdens and costs on them.

Senator Joe Manchin III, Democrat of West Virginia, expressed dismay when the proposal died in the House of Representatives.

“They got their victory – but not at my expense,” said Mr. Manchin, whose state has been hard hit by prescription drug abuse. “The people who will pay the price are the young boys and girls in communities across this nation.”

Dr. Woodcock, the F.D.A. official, said that requiring patients with long-lasting pain to see a doctor after three months, rather than six, to get a new prescription could benefit them.

“If you are needing chronic therapy of this magnitude, you should be seeing your prescriber,” she said.

Earlier this year, an expert advisory panel to the F.D.A. voted 19 to 10 in favor of reclassifying hydrocodone-containing painkillers as Schedule II drugs. While such recommendations are not binding, the agency often follows them.

Along with changing how doctors prescribe these drugs, the classification change will also impose added storage and recordkeeping requirements on druggists. In some states, nurse practitioners and other health care professionals who can currently prescribe hydrocodone-containing drugs may no longer be able to do so.
 
Fantastic news! Finally some logical thought and regulations regarding hydrocodone, a drug equipotent to CII morphine.
 
This change occurred in my state a few months ago.

Odd that I haven't read any woe is me articles about the change in Schedule.

the effects have only been positive...
 
http://www.medpagetoday.com/MeetingCoverage/WCN/41941


Now the Neurologists want to Rx oxycodone for RLS.

Sounds like a bad idea.

Oh yeah! Opioids are apparently one of the standard treatments for RLS. The neurologists in my practice are all about it. The neurologists back at the VA would also do it. I mean, really? You could use oxy for about any malady that's "uncomfortable". It's most likely gonna make you feel better in some way. That doesn't mean the risk/benefit profile is favorable. I agree Steve
 
Wonder if any of these companies make oxycodone- naloxone?

[/quote]
Trenkwalder reported relationships with Vifor, UCB, Mundipharma, Britannia, Novartis, Boehringer Ingelheim, GlaxoSmithKline, TEVA, and Destin.
[/unquote]
 
Oh yeah! Opioids are apparently one of the standard treatments for RLS. The neurologists in my practice are all about it. The neurologists back at the VA would also do it. I mean, really? You could use oxy for about any malady that's "uncomfortable". It's most likely gonna make you feel better in some way. That doesn't mean the risk/benefit profile is favorable. I agree Steve


I didn't realize for RLS, the legs were 'painful', just thought it was 'restless'. So why the oxycodone?

Interesting, when I give pts Gabapentin for radiculitis, they have often times come back and told me that their "RLS" is gone :eek:
 
1. http://www.fda.gov/downloads/Drugs/NewsEvents/UCM300859.pdf
2. Len Paulozzi (CDC):

Now 4 independent studies demonstrating a direct link between MED and unintentional opioid overdose death. Time to starting incorporating MED in to risk stratification documents. HIGH DOSE = HIGH RISK.

1. A history of being prescribed controlled substances and risk of drug overdose death.
Paulozzi LJ, Kilbourne EM, Shah NG, Nolte KB, Desai HA, Landen MG, Harvey W, Loring LD. Pain Med. 2012 Jan;13(1):87-95. doi: 10.1111/j.1526-4637.2011.01260.x. Epub 2011 Oct 25.

2. Opioid dose and drug-related mortality in patients with nonmalignant pain.
Gomes T, Mamdani MM, Dhalla IA, Paterson JM, Juurlink DN. Arch Intern Med. 2011 Apr 11;171(7):686-91. doi: 10.1001/archinternmed.2011.117.

3. Association between opioid prescribing patterns and opioid overdose-related deaths.
Bohnert AS, Valenstein M, Bair MJ, Ganoczy D, McCarthy JF, Ilgen MA, Blow FC.
JAMA. 2011 Apr 6;305(13):1315-21. doi: 10.1001/jama.2011.370.

4. Opioid prescriptions for chronic pain and overdose: a cohort study.
Dunn KM, Saunders KW, Rutter CM, Banta-Green CJ, Merrill JO, Sullivan MD, Weisner CM, Silverberg MJ, Campbell CI, Psaty BM, Von Korff M. Ann Intern Med. 2010 Jan 19;152(2):85-92. doi: 10.7326/0003-4819-152-2-201001190-00006.
 
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