I absolutely love the Orlando Campus. It's by far the newest of the four (soon to be three campuses). It sits in Lake Nona which is known as medical city so it's surrounded by UCF College of Medicine, a VA hospital that is supposed to open this year, Nemour's Children's Hospital, Sanford Burnham Research, and soon to be much more. It's still a growing area so most of the housing is 10-15 minutes away but parking is never a problem and it's highway the whole way so it's a nice commute. Orlando has more than I could ever ask for as far as things to do goes.
As far as classes go I suppose I can't fully comment on how different they are being as I've never attended a live lecture in Gainesville yet. I will comment that many students in Gainesville opt to just watch the recorded lectures rather than attend the live lectures due to many reasons. It took a little while to get adjusted to watching recorded lectures but now it would be so hard to go back. First off the convenience to be able to watch the lectures whenever you please is amazing. Second off you control everything and can pause or rewind as you please to reinforce a topic or if you just need a quick break... The best thing however is double speed (you'll soon to grow to love this to the point that normal conversations sound like they're being played in slo-mo)! Double speed is a must because they do dump a lot of lectures on you on top of the classes that you're already having live on the distance campuses.
The only downside I see to being at a distance campus is all the big events like orientation, SOAR, and white coat ceremony (coming up in a couple weeks for us) are all performed in Gainesville so we all have to commute up for those. There are however many Pharmacy related events held here in Orlando being that it is such a large hub city. Many of the other campuses drive down for some of the Board of Pharmacy meetings here, PDS (which is the National Independent Pharmacy Growth Conference), and many others! In the end they're all great campuses (I'm often jealous of the St. Pete kids always posting pictures studying by the beach... but you guys don't get the option to go to that campus) so no matter which one you end up at I'm sure you'll be happy. I'm also not completely positive but I've heard that once you're in, that if you do decide to change campuses, that they make it very easy after your first year... However the friendships that you make your first year will never make you want to transfer campuses.