Surely you would have some sort of emergency procedure in place? In our hospital, the house supervisor has a keycard to the pharmacy, and can enter the pharmacy and remove drugs in the event of an emergency (there is a documentation form s/he would have to fill out in this event, and there are rules like s/he can't remove IV drugs that would have to be diluted before given, s/he would have to mix them in the pharmacy) Because pretty much everything that conceivably would be needed is in the omnicell/pyxis or crash cart (and the house supervisor would first go to another unit to get a needed drug from an omnicell/pyxis/crash cart if it were not available or had been depleted from one unit), it would be extremely rare for a such a confluence of events to occur--ie the pharmacist on duty had to close the pharmacy due to a medical emergency and then a flux of new admissions depleted some needed drug out of all the omnicells/pyxis/crashcarts in the entire hospital, etc. But there is a policy, just in case. Most likely your pharmacy has a similar policy, you just don't know about it, because its never had to be used--if not, you should have such a policy.