Where do B-cells mature?

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anondukie

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The Kaplan review book mentions the spleen and lymph nodes in one chapter and the bone marrow in another.
Is the consensus that they mature in the bone marrow and are activated in the spleen and lymph nodes?

What about T-cells? Formed in the bone marrow and mature in the thymus? Do they need "activating"?

Thanks!

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The Kaplan review book mentions the spleen and lymph nodes in one chapter and the bone marrow in another.
Is the consensus that they mature in the bone marrow and are activated in the spleen and lymph nodes?

What about T-cells? Formed in the bone marrow and mature in the thymus? Do they need "activating"?

Thanks!

T-cells definitely mature in thymus during childhood. I think T and B cells both are formed in bone marrow just like the other components of blood, but would like to hear what others think.
 
T-cells and B-cells are formed in the bone marrow. B-cells mature in the bone marrow, while T-cells mature in the thymus. Both t-cells and b-cells are activated in secondary lymph tissue, such as lymph nodes.
 
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